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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR1E
All Species:
15.45
Human Site:
T227
Identified Species:
30.91
UniProt:
P28566
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P28566
NP_000856.1
365
41682
T227
R
H
L
S
N
R
S
T
D
S
Q
N
S
F
A
Chimpanzee
Pan troglodytes
Q9N2B6
363
41425
T227
R
H
L
S
N
R
S
T
D
S
Q
N
S
F
A
Rhesus Macaque
Macaca mulatta
XP_001090567
365
41663
T227
R
H
L
S
N
R
S
T
D
S
Q
N
S
F
A
Dog
Lupus familis
XP_539028
365
41558
T227
R
H
L
S
N
R
S
T
D
S
Q
N
S
F
A
Cat
Felis silvestris
Mouse
Mus musculus
Q02284
366
41959
Q228
I
K
E
E
L
N
G
Q
V
F
L
E
S
G
E
Rat
Rattus norvegicus
P30940
366
41862
Q228
I
K
E
E
L
N
G
Q
V
L
L
E
S
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513201
350
39774
T226
A
S
C
K
L
T
Q
T
F
C
V
S
D
F
S
Chicken
Gallus gallus
XP_001235179
364
41254
D227
H
L
S
N
R
S
T
D
S
Q
N
S
F
A
S
Frog
Xenopus laevis
Q98998
408
45769
T235
E
K
K
K
V
A
D
T
C
L
S
V
S
Q
Q
Zebra Danio
Brachydanio rerio
XP_002665689
378
42567
D239
H
L
S
S
R
S
T
D
S
Q
T
S
F
N
H
Tiger Blowfish
Takifugu rubipres
O42384
416
47013
K238
T
V
R
K
T
E
K
K
K
V
S
D
T
C
L
Fruit Fly
Dros. melanogaster
P20905
564
60843
L367
Q
T
H
L
Q
Q
A
L
N
G
T
G
S
P
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.6
94.5
N.A.
54.6
54.6
N.A.
87.9
86.5
37.2
64.5
39.4
26.6
N.A.
N.A.
N.A.
Protein Similarity:
100
99.4
99.1
97.5
N.A.
72.1
72.1
N.A.
91.7
92.8
55.6
76.1
55.7
41.1
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
6.6
6.6
N.A.
13.3
0
13.3
6.6
0
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
6.6
6.6
N.A.
26.6
26.6
13.3
20
13.3
40
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
9
9
0
0
0
0
0
0
9
34
% A
% Cys:
0
0
9
0
0
0
0
0
9
9
0
0
0
9
0
% C
% Asp:
0
0
0
0
0
0
9
17
34
0
0
9
9
0
0
% D
% Glu:
9
0
17
17
0
9
0
0
0
0
0
17
0
0
17
% E
% Phe:
0
0
0
0
0
0
0
0
9
9
0
0
17
42
0
% F
% Gly:
0
0
0
0
0
0
17
0
0
9
0
9
0
17
0
% G
% His:
17
34
9
0
0
0
0
0
0
0
0
0
0
0
9
% H
% Ile:
17
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
25
9
25
0
0
9
9
9
0
0
0
0
0
0
% K
% Leu:
0
17
34
9
25
0
0
9
0
17
17
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
34
17
0
0
9
0
9
34
0
9
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% P
% Gln:
9
0
0
0
9
9
9
17
0
17
34
0
0
9
9
% Q
% Arg:
34
0
9
0
17
34
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
9
17
42
0
17
34
0
17
34
17
25
67
0
25
% S
% Thr:
9
9
0
0
9
9
17
50
0
0
17
0
9
0
0
% T
% Val:
0
9
0
0
9
0
0
0
17
9
9
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _