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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERCC5
All Species:
19.7
Human Site:
S648
Identified Species:
36.11
UniProt:
P28715
Number Species:
12
Phosphosite Substitution
Charge Score:
0.42
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P28715
NP_000114.2
1186
133108
S648
M
E
I
D
S
E
E
S
E
S
D
G
S
F
I
Chimpanzee
Pan troglodytes
XP_509723
1754
197217
S1216
M
E
I
D
S
E
E
S
E
S
D
G
S
F
I
Rhesus Macaque
Macaca mulatta
XP_001096257
1730
194783
S1196
M
E
I
D
S
E
E
S
E
S
D
G
S
F
I
Dog
Lupus familis
XP_542659
1194
133696
S649
M
E
M
D
S
E
E
S
E
S
D
G
S
F
I
Cat
Felis silvestris
Mouse
Mus musculus
P35689
1170
130839
S648
M
E
M
E
S
E
E
S
E
S
D
G
S
F
I
Rat
Rattus norvegicus
NP_001100380
862
96082
G355
I
Q
V
A
M
L
G
G
S
S
E
E
E
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513433
1466
166007
T914
K
N
D
F
S
S
E
T
W
M
P
D
A
Q
L
Chicken
Gallus gallus
NP_001029995
1118
126986
E604
R
E
G
A
S
Q
S
E
D
S
D
S
D
G
S
Frog
Xenopus laevis
P14629
1196
134188
E675
E
S
I
I
V
S
D
E
E
F
V
N
E
K
E
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001027230
1236
138998
L652
I
S
S
I
L
D
E
L
K
V
K
M
A
D
V
Honey Bee
Apis mellifera
XP_393585
1047
119475
E540
S
D
S
D
D
F
I
E
I
K
D
I
P
A
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_791943
1102
123652
D595
R
K
V
F
K
E
E
D
R
A
M
T
Q
R
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ATY5
1479
165649
E640
E
E
E
A
D
L
Q
E
A
I
K
K
S
L
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67
64.7
74.5
N.A.
65.7
50
N.A.
49.7
54.7
50.3
N.A.
N.A.
29.2
29.4
N.A.
22.9
Protein Similarity:
100
67.3
66.3
84.2
N.A.
77.2
57.7
N.A.
62
69.6
64.3
N.A.
N.A.
50.8
48.8
N.A.
41.3
P-Site Identity:
100
100
100
93.3
N.A.
86.6
6.6
N.A.
13.3
26.6
13.3
N.A.
N.A.
6.6
13.3
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
33.3
40
20
N.A.
N.A.
40
20
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
25.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
24
0
0
0
0
8
8
0
0
16
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
8
39
16
8
8
8
8
0
54
8
8
8
0
% D
% Glu:
16
54
8
8
0
47
62
31
47
0
8
8
16
0
16
% E
% Phe:
0
0
0
16
0
8
0
0
0
8
0
0
0
39
0
% F
% Gly:
0
0
8
0
0
0
8
8
0
0
0
39
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
16
0
31
16
0
0
8
0
8
8
0
8
0
0
39
% I
% Lys:
8
8
0
0
8
0
0
0
8
8
16
8
0
8
0
% K
% Leu:
0
0
0
0
8
16
0
8
0
0
0
0
0
8
16
% L
% Met:
39
0
16
0
8
0
0
0
0
8
8
8
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
0
8
8
0
% P
% Gln:
0
8
0
0
0
8
8
0
0
0
0
0
8
8
8
% Q
% Arg:
16
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% R
% Ser:
8
16
16
0
54
16
8
39
8
54
0
8
47
0
16
% S
% Thr:
0
0
0
0
0
0
0
8
0
0
0
8
0
0
0
% T
% Val:
0
0
16
0
8
0
0
0
0
8
8
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _