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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERCC5
All Species:
21.82
Human Site:
Y144
Identified Species:
40
UniProt:
P28715
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P28715
NP_000114.2
1186
133108
Y144
V
R
R
E
N
D
L
Y
V
L
P
P
L
Q
E
Chimpanzee
Pan troglodytes
XP_509723
1754
197217
Y712
V
R
R
E
N
D
I
Y
V
L
P
P
L
Q
E
Rhesus Macaque
Macaca mulatta
XP_001096257
1730
194783
Y692
V
R
R
E
N
D
M
Y
V
L
P
P
L
Q
E
Dog
Lupus familis
XP_542659
1194
133696
Y144
V
R
R
E
D
D
I
Y
V
L
P
P
L
Q
K
Cat
Felis silvestris
Mouse
Mus musculus
P35689
1170
130839
Y144
V
Q
R
Q
D
D
I
Y
V
L
P
P
L
P
E
Rat
Rattus norvegicus
NP_001100380
862
96082
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513433
1466
166007
D403
V
H
R
A
K
V
D
D
I
F
I
L
P
S
L
Chicken
Gallus gallus
NP_001029995
1118
126986
Y131
T
G
K
S
N
E
V
Y
P
S
I
T
Q
V
R
Frog
Xenopus laevis
P14629
1196
134188
T144
S
Q
V
P
R
K
E
T
E
D
L
Y
I
L
P
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001027230
1236
138998
N144
R
P
P
P
A
K
K
N
D
E
D
D
L
F
K
Honey Bee
Apis mellifera
XP_393585
1047
119475
Y67
H
R
I
C
K
L
L
Y
Y
K
I
K
P
I
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_791943
1102
123652
E122
A
I
Q
A
V
I
G
E
N
G
E
G
T
S
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ATY5
1479
165649
S144
D
R
V
K
K
R
V
S
S
D
S
V
E
D
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67
64.7
74.5
N.A.
65.7
50
N.A.
49.7
54.7
50.3
N.A.
N.A.
29.2
29.4
N.A.
22.9
Protein Similarity:
100
67.3
66.3
84.2
N.A.
77.2
57.7
N.A.
62
69.6
64.3
N.A.
N.A.
50.8
48.8
N.A.
41.3
P-Site Identity:
100
93.3
93.3
80
N.A.
66.6
0
N.A.
13.3
13.3
0
N.A.
N.A.
6.6
20
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
0
N.A.
20
33.3
13.3
N.A.
N.A.
13.3
20
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
25.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
16
8
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
16
39
8
8
8
16
8
8
0
8
0
% D
% Glu:
0
0
0
31
0
8
8
8
8
8
8
0
8
0
31
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
8
% F
% Gly:
0
8
0
0
0
0
8
0
0
8
0
8
0
0
0
% G
% His:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
8
24
0
8
0
24
0
8
8
0
% I
% Lys:
0
0
8
8
24
16
8
0
0
8
0
8
0
0
16
% K
% Leu:
0
0
0
0
0
8
16
0
0
39
8
8
47
8
8
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
31
0
0
8
8
0
0
0
0
0
8
% N
% Pro:
0
8
8
16
0
0
0
0
8
0
39
39
16
8
8
% P
% Gln:
0
16
8
8
0
0
0
0
0
0
0
0
8
31
8
% Q
% Arg:
8
47
47
0
8
8
0
0
0
0
0
0
0
0
8
% R
% Ser:
8
0
0
8
0
0
0
8
8
8
8
0
0
16
0
% S
% Thr:
8
0
0
0
0
0
0
8
0
0
0
8
8
0
0
% T
% Val:
47
0
16
0
8
8
16
0
39
0
0
8
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
54
8
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _