KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD11B1
All Species:
4.55
Human Site:
S281
Identified Species:
8.33
UniProt:
P28845
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P28845
NP_005516.1
292
32401
S281
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
Chimpanzee
Pan troglodytes
XP_001168226
292
32354
S281
K
I
L
E
F
L
Y
S
T
S
Y
N
M
D
R
Rhesus Macaque
Macaca mulatta
XP_001110531
292
32393
L281
K
I
L
E
F
L
Y
L
P
S
Y
N
M
D
R
Dog
Lupus familis
XP_542145
223
23905
L212
I
T
M
C
V
L
G
L
R
D
R
A
S
A
A
Cat
Felis silvestris
Mouse
Mus musculus
P50172
292
32345
L281
K
I
M
E
F
F
S
L
R
Y
Y
N
K
D
M
Rat
Rattus norvegicus
P16232
288
31865
L277
R
I
M
E
F
L
S
L
R
S
Y
N
R
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510050
476
52232
G326
E
L
Q
A
E
L
A
G
L
S
D
E
Y
L
S
Chicken
Gallus gallus
Q6PUF4
287
31460
V270
Q
P
V
H
G
L
W
V
L
L
P
N
P
R
V
Frog
Xenopus laevis
Q6P7J1
291
31734
L281
P
G
L
V
A
K
I
L
D
N
F
Y
I
L
E
Zebra Danio
Brachydanio rerio
Q6PUF3
287
31899
W270
Y
A
T
L
F
R
D
W
F
P
Y
L
R
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
H301
K
I
A
Y
Y
L
R
H
L
C
P
S
L
Y
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001197619
254
28550
D243
Q
P
F
V
M
V
R
D
L
L
P
G
W
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q05016
267
29140
N257
D
T
L
I
F
P
T
N
Q
A
S
P
H
H
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.8
35.6
N.A.
78.4
75.6
N.A.
38.6
42.4
45.2
43.1
N.A.
24.8
N.A.
N.A.
38.3
Protein Similarity:
100
100
97.9
48.2
N.A.
87.6
87.3
N.A.
51
60.2
69.1
61.2
N.A.
43.5
N.A.
N.A.
54.1
P-Site Identity:
100
100
86.6
6.6
N.A.
46.6
53.3
N.A.
13.3
13.3
6.6
20
N.A.
20
N.A.
N.A.
6.6
P-Site Similarity:
100
100
86.6
13.3
N.A.
53.3
66.6
N.A.
26.6
33.3
26.6
26.6
N.A.
40
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
38.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
8
8
0
8
0
0
8
0
8
0
8
8
% A
% Cys:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
8
8
8
8
8
0
0
54
8
% D
% Glu:
8
0
0
39
8
0
0
0
0
0
0
8
0
0
8
% E
% Phe:
0
0
8
0
54
8
0
0
8
0
8
0
0
0
8
% F
% Gly:
0
8
0
0
8
0
8
8
0
0
0
8
0
0
0
% G
% His:
0
0
0
8
0
0
0
8
0
0
0
0
8
8
0
% H
% Ile:
8
47
0
8
0
0
8
0
0
0
0
0
8
0
8
% I
% Lys:
39
0
0
0
0
8
0
0
0
0
0
0
8
0
8
% K
% Leu:
0
8
39
8
0
62
0
39
31
16
0
8
8
16
8
% L
% Met:
0
0
24
0
8
0
0
0
0
0
0
0
24
0
8
% M
% Asn:
0
0
0
0
0
0
0
8
0
8
0
47
0
0
0
% N
% Pro:
8
16
0
0
0
8
0
0
8
8
24
8
8
0
0
% P
% Gln:
16
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
8
16
0
24
0
8
0
16
8
24
% R
% Ser:
0
0
0
0
0
0
16
16
0
39
8
8
8
0
8
% S
% Thr:
0
16
8
0
0
0
8
0
16
0
0
0
0
0
0
% T
% Val:
0
0
8
16
8
8
0
8
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
8
8
0
0
0
0
8
0
0
% W
% Tyr:
8
0
0
8
8
0
24
0
0
8
47
8
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _