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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD11B1
All Species:
20.91
Human Site:
Y21
Identified Species:
38.33
UniProt:
P28845
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P28845
NP_005516.1
292
32401
Y21
L
F
M
A
Y
Y
Y
Y
S
A
N
E
E
F
R
Chimpanzee
Pan troglodytes
XP_001168226
292
32354
Y21
L
F
M
A
Y
Y
Y
Y
S
A
N
E
E
F
R
Rhesus Macaque
Macaca mulatta
XP_001110531
292
32393
Y21
L
F
M
A
Y
Y
Y
Y
S
A
Y
E
E
F
R
Dog
Lupus familis
XP_542145
223
23905
Cat
Felis silvestris
Mouse
Mus musculus
P50172
292
32345
Y21
L
F
L
A
Y
Y
Y
Y
S
T
N
E
E
F
R
Rat
Rattus norvegicus
P16232
288
31865
E22
Y
Y
Y
S
T
N
E
E
F
R
P
E
M
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510050
476
52232
Y21
L
L
L
A
Y
Y
F
Y
S
S
P
E
F
K
P
Chicken
Gallus gallus
Q6PUF4
287
31460
F21
S
L
A
V
L
L
A
F
F
W
R
D
T
F
Q
Frog
Xenopus laevis
Q6P7J1
291
31734
Y21
G
Y
T
A
Y
H
F
Y
S
S
E
S
M
N
P
Zebra Danio
Brachydanio rerio
Q6PUF3
287
31899
S22
A
F
I
A
V
R
W
S
A
P
S
F
N
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
I38
L
P
L
A
I
I
N
I
W
Q
R
F
Q
A
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001197619
254
28550
T10
K
G
K
R
V
I
L
T
G
A
S
T
G
I
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q05016
267
29140
A21
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.8
35.6
N.A.
78.4
75.6
N.A.
38.6
42.4
45.2
43.1
N.A.
24.8
N.A.
N.A.
38.3
Protein Similarity:
100
100
97.9
48.2
N.A.
87.6
87.3
N.A.
51
60.2
69.1
61.2
N.A.
43.5
N.A.
N.A.
54.1
P-Site Identity:
100
100
93.3
0
N.A.
86.6
6.6
N.A.
46.6
6.6
26.6
13.3
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
100
93.3
0
N.A.
93.3
26.6
N.A.
66.6
26.6
53.3
40
N.A.
33.3
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
38.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
62
0
0
8
8
8
39
0
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% D
% Glu:
0
0
0
0
0
0
8
8
0
0
8
47
31
8
8
% E
% Phe:
0
39
0
0
0
0
16
8
16
0
0
16
8
39
0
% F
% Gly:
8
8
0
0
0
0
8
0
8
0
8
0
16
0
8
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
16
16
0
8
0
0
0
8
0
8
0
% I
% Lys:
16
0
8
0
0
0
0
0
0
0
0
0
0
16
0
% K
% Leu:
47
16
24
8
8
8
8
0
0
0
0
0
0
8
0
% L
% Met:
0
0
24
0
0
0
0
0
0
0
0
0
16
0
0
% M
% Asn:
0
0
0
0
0
8
8
0
0
0
24
0
8
8
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
8
16
0
0
0
16
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
24
% Q
% Arg:
0
0
0
8
0
8
0
0
0
8
16
0
0
0
31
% R
% Ser:
8
0
0
8
0
0
0
8
54
16
16
8
0
0
0
% S
% Thr:
0
8
8
0
8
8
0
8
0
8
0
8
8
0
0
% T
% Val:
0
0
8
8
16
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
8
0
8
8
0
0
0
0
0
% W
% Tyr:
8
16
8
0
47
39
31
47
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _