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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD11B1
All Species:
16.06
Human Site:
Y257
Identified Species:
29.44
UniProt:
P28845
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P28845
NP_005516.1
292
32401
Y257
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
Chimpanzee
Pan troglodytes
XP_001168226
292
32354
Y257
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
Rhesus Macaque
Macaca mulatta
XP_001110531
292
32393
Y257
A
L
R
Q
E
E
V
Y
Y
D
S
S
L
W
T
Dog
Lupus familis
XP_542145
223
23905
F188
A
K
F
A
L
D
G
F
F
G
S
L
R
R
E
Cat
Felis silvestris
Mouse
Mus musculus
P50172
292
32345
Y257
A
L
R
K
S
E
V
Y
Y
D
K
S
P
L
T
Rat
Rattus norvegicus
P16232
288
31865
Y253
V
L
R
K
D
E
V
Y
Y
D
K
S
S
W
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510050
476
52232
L302
V
N
K
D
Q
T
S
L
S
K
E
I
M
G
C
Chicken
Gallus gallus
Q6PUF4
287
31460
I246
A
E
A
A
L
A
I
I
R
G
G
A
A
R
L
Frog
Xenopus laevis
Q6P7J1
291
31734
F257
V
L
K
Q
P
E
L
F
Y
P
Y
W
G
I
K
Zebra Danio
Brachydanio rerio
Q6PUF3
287
31899
Q246
E
A
A
L
Q
I
I
Q
A
G
A
T
R
Q
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
Q277
K
L
A
E
R
I
L
Q
C
I
L
R
K
E
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001197619
254
28550
L219
E
D
T
A
Y
R
I
L
E
G
T
A
M
R
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q05016
267
29140
A233
P
L
M
A
D
D
V
A
D
L
I
V
Y
A
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.8
35.6
N.A.
78.4
75.6
N.A.
38.6
42.4
45.2
43.1
N.A.
24.8
N.A.
N.A.
38.3
Protein Similarity:
100
100
97.9
48.2
N.A.
87.6
87.3
N.A.
51
60.2
69.1
61.2
N.A.
43.5
N.A.
N.A.
54.1
P-Site Identity:
100
100
100
13.3
N.A.
66.6
66.6
N.A.
0
6.6
26.6
0
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
100
100
33.3
N.A.
73.3
80
N.A.
20
20
46.6
33.3
N.A.
20
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
38.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
8
24
31
0
8
0
8
8
0
8
16
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% C
% Asp:
0
8
0
8
16
16
0
0
8
39
0
0
0
0
0
% D
% Glu:
16
8
0
8
24
47
0
0
8
0
8
0
0
8
16
% E
% Phe:
0
0
8
0
0
0
0
16
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
31
8
0
8
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
16
24
8
0
8
8
8
0
8
0
% I
% Lys:
8
8
16
16
0
0
0
0
0
8
16
0
8
0
8
% K
% Leu:
0
62
0
8
16
0
16
16
0
8
8
8
24
8
8
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
16
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
0
0
0
8
0
0
0
0
8
0
0
8
0
8
% P
% Gln:
0
0
0
31
16
0
0
16
0
0
0
0
0
8
0
% Q
% Arg:
0
0
39
0
8
8
0
0
8
0
0
8
16
24
0
% R
% Ser:
0
0
0
0
8
0
8
0
8
0
31
39
8
0
8
% S
% Thr:
0
0
8
0
0
8
0
0
0
0
8
8
0
0
47
% T
% Val:
24
0
0
0
0
0
47
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
31
0
% W
% Tyr:
0
0
0
0
8
0
0
39
47
0
8
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _