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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GJB2 All Species: 31.82
Human Site: T177 Identified Species: 77.78
UniProt: P29033 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29033 NP_003995.2 226 26215 T177 N A W P C P N T V D C F V S R
Chimpanzee Pan troglodytes XP_001145895 209 24152 V161 A W P C P N T V D C F V S R P
Rhesus Macaque Macaca mulatta Q8MIT8 226 26206 T177 N A W P C P N T V D C F V S R
Dog Lupus familis XP_543177 226 26241 T177 N A W P C P N T V D C F V S R
Cat Felis silvestris
Mouse Mus musculus Q00977 226 26393 T177 N A W P C P N T V D C F I S R
Rat Rattus norvegicus P21994 226 26433 T177 N A W P C P N T V D C F I S R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516368 226 26252 T177 N A W P C P N T V D C F V S R
Chicken Gallus gallus O93533 263 30905 T177 S A W P C P N T V D C F V S R
Frog Xenopus laevis P08983 264 29977 T176 D A Y P C P N T V D C F V S R
Zebra Danio Brachydanio rerio NP_997990 267 30305 K179 E Q W P C P N K V D C F I S R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.4 98.2 98.6 N.A. 92.9 93.8 N.A. 93.8 71.8 56 58.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 92.4 99.5 99.1 N.A. 98.2 98.2 N.A. 96.9 79 71.9 68.9 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 100 100 N.A. 93.3 93.3 N.A. 100 93.3 86.6 73.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 0 100 100 N.A. 100 100 N.A. 100 100 100 80 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 80 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 10 90 0 0 0 0 10 90 0 0 0 0 % C
% Asp: 10 0 0 0 0 0 0 0 10 90 0 0 0 0 0 % D
% Glu: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 10 90 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 30 0 0 % I
% Lys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 60 0 0 0 0 10 90 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 10 90 10 90 0 0 0 0 0 0 0 0 10 % P
% Gln: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 90 % R
% Ser: 10 0 0 0 0 0 0 0 0 0 0 0 10 90 0 % S
% Thr: 0 0 0 0 0 0 10 80 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 10 90 0 0 10 60 0 0 % V
% Trp: 0 10 80 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _