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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN4
All Species:
30
Human Site:
S440
Identified Species:
55
UniProt:
P29074
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29074
NP_002821.1
926
105911
S440
V
N
Q
R
S
P
S
S
T
Q
A
N
S
I
V
Chimpanzee
Pan troglodytes
XP_525902
926
105888
S440
V
N
Q
R
S
P
S
S
T
Q
A
N
S
I
V
Rhesus Macaque
Macaca mulatta
XP_001084627
926
105879
S440
V
N
Q
R
S
P
S
S
T
Q
A
N
S
I
V
Dog
Lupus familis
XP_541002
926
105853
S440
V
N
H
R
S
P
S
S
T
Q
A
N
S
I
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9WU22
926
105695
S440
V
S
Q
R
S
P
S
S
T
Q
A
N
S
I
V
Rat
Rattus norvegicus
Q9WTP0
879
98224
Y425
E
R
S
S
S
K
R
Y
T
M
S
R
S
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506800
952
108609
S480
S
P
P
T
Q
N
P
S
E
N
S
T
A
P
N
Chicken
Gallus gallus
XP_422082
929
106145
S443
V
N
H
R
S
P
S
S
T
Q
A
N
S
I
I
Frog
Xenopus laevis
NP_001084871
929
106368
S443
N
N
H
Q
S
S
S
S
T
Q
A
N
S
I
V
Zebra Danio
Brachydanio rerio
O57457
619
70690
D172
F
V
P
D
Q
K
E
D
L
E
D
S
I
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V8R9
1698
184149
V676
S
A
V
D
A
A
A
V
P
L
S
D
S
Q
K
Honey Bee
Apis mellifera
XP_623968
927
104994
S465
A
F
S
P
V
L
G
S
R
V
L
S
Y
A
D
Nematode Worm
Caenorhab. elegans
P28191
1026
115075
S485
T
P
S
M
A
C
T
S
T
S
P
G
I
H
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.4
97.3
N.A.
94.1
28.5
N.A.
51.8
92.2
84.2
26.2
N.A.
21.4
50.7
41.1
N.A.
Protein Similarity:
100
99.8
99.7
99.1
N.A.
97.5
44.5
N.A.
68.4
96.6
90.5
40.2
N.A.
34
66.3
59
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
20
N.A.
6.6
86.6
73.3
0
N.A.
6.6
6.6
13.3
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
33.3
N.A.
20
93.3
80
13.3
N.A.
33.3
13.3
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
16
8
8
0
0
0
54
0
8
8
8
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
16
0
0
0
8
0
0
8
8
0
0
16
% D
% Glu:
8
0
0
0
0
0
8
0
8
8
0
0
0
8
0
% E
% Phe:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% G
% His:
0
0
24
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
16
54
8
% I
% Lys:
0
0
0
0
0
16
0
0
0
0
0
0
0
0
8
% K
% Leu:
0
0
0
0
0
8
0
0
8
8
8
0
0
8
0
% L
% Met:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
8
47
0
0
0
8
0
0
0
8
0
54
0
0
8
% N
% Pro:
0
16
16
8
0
47
8
0
8
0
8
0
0
8
0
% P
% Gln:
0
0
31
8
16
0
0
0
0
54
0
0
0
8
8
% Q
% Arg:
0
8
0
47
0
0
8
0
8
0
0
8
0
0
0
% R
% Ser:
16
8
24
8
62
8
54
77
0
8
24
16
70
0
0
% S
% Thr:
8
0
0
8
0
0
8
0
70
0
0
8
0
0
0
% T
% Val:
47
8
8
0
8
0
0
8
0
8
0
0
0
0
47
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _