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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK1
All Species:
23.64
Human Site:
S116
Identified Species:
43.33
UniProt:
P29120
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29120
NP_000430.3
753
84152
S116
K
R
S
A
L
R
D
S
A
L
N
L
F
N
D
Chimpanzee
Pan troglodytes
XP_517645
753
84134
S116
K
R
S
A
L
R
D
S
A
L
N
L
F
N
D
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
L109
K
R
R
T
K
R
D
L
Y
Q
E
P
T
D
P
Dog
Lupus familis
XP_848637
753
84126
S116
K
R
S
V
L
R
D
S
A
L
N
L
F
N
D
Cat
Felis silvestris
Mouse
Mus musculus
P63239
753
84155
S116
K
R
S
V
Q
K
D
S
A
L
D
L
F
N
D
Rat
Rattus norvegicus
P28840
752
84102
S116
K
R
S
V
P
R
D
S
A
L
N
L
F
N
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512273
758
84714
S122
K
R
S
V
L
R
D
S
A
N
N
L
F
N
D
Chicken
Gallus gallus
Frog
Xenopus laevis
P29119
783
86425
T109
R
K
K
R
D
I
Y
T
D
P
T
D
P
K
F
Zebra Danio
Brachydanio rerio
NP_001131134
755
84185
E114
K
R
A
P
L
G
V
E
C
K
D
C
S
V
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
R315
K
R
D
F
I
R
M
R
P
S
R
T
S
S
R
Honey Bee
Apis mellifera
XP_393918
714
80231
S124
K
R
D
Y
V
P
L
S
S
L
D
S
E
K
P
Nematode Worm
Caenorhab. elegans
P51559
943
103128
D122
K
R
D
Y
I
L
L
D
N
D
V
H
H
S
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
P115
K
R
L
P
V
P
A
P
P
M
D
S
S
L
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
42.9
96.4
N.A.
92.5
92.6
N.A.
78.2
N.A.
41.2
72.5
N.A.
32.6
44
33.8
N.A.
Protein Similarity:
100
100
58.5
97.8
N.A.
96.4
96.1
N.A.
84.4
N.A.
57.4
84.1
N.A.
45.7
58.7
49.4
N.A.
P-Site Identity:
100
100
26.6
93.3
N.A.
73.3
86.6
N.A.
86.6
N.A.
0
26.6
N.A.
20
26.6
13.3
N.A.
P-Site Similarity:
100
100
33.3
93.3
N.A.
86.6
86.6
N.A.
86.6
N.A.
20
40
N.A.
33.3
46.6
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
16
0
0
8
0
47
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
8
0
0
0
% C
% Asp:
0
0
24
0
8
0
54
8
8
8
31
8
0
8
54
% D
% Glu:
0
0
0
0
0
0
0
8
0
0
8
0
8
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
0
47
0
8
% F
% Gly:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% H
% Ile:
0
0
0
0
16
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
93
8
8
0
8
8
0
0
0
8
0
0
0
16
0
% K
% Leu:
0
0
8
0
39
8
16
8
0
47
0
47
0
8
8
% L
% Met:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
8
39
0
0
47
8
% N
% Pro:
0
0
0
16
8
16
0
8
16
8
0
8
8
0
16
% P
% Gln:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
8
93
8
8
0
54
0
8
0
0
8
0
0
0
8
% R
% Ser:
0
0
47
0
0
0
0
54
8
8
0
16
24
16
0
% S
% Thr:
0
0
0
8
0
0
0
8
0
0
8
8
8
0
0
% T
% Val:
0
0
0
31
16
0
8
0
0
0
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
16
0
0
8
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _