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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK1
All Species:
41.21
Human Site:
S335
Identified Species:
75.56
UniProt:
P29120
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29120
NP_000430.3
753
84152
S335
T
I
S
I
S
S
A
S
Q
Q
G
L
S
P
W
Chimpanzee
Pan troglodytes
XP_517645
753
84134
S335
T
I
S
I
S
S
A
S
Q
Q
G
L
S
P
W
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
T321
T
L
S
I
S
S
A
T
Q
F
G
N
V
P
W
Dog
Lupus familis
XP_848637
753
84126
S335
T
I
S
I
S
S
A
S
Q
Q
G
L
S
P
W
Cat
Felis silvestris
Mouse
Mus musculus
P63239
753
84155
S335
T
I
S
I
S
S
A
S
Q
Q
G
L
S
P
W
Rat
Rattus norvegicus
P28840
752
84102
S335
T
I
S
I
S
S
A
S
Q
Q
G
L
S
P
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512273
758
84714
S341
T
I
S
I
S
S
A
S
Q
Q
G
L
S
P
W
Chicken
Gallus gallus
Frog
Xenopus laevis
P29119
783
86425
T319
T
L
S
I
S
S
T
T
Q
M
G
N
V
P
W
Zebra Danio
Brachydanio rerio
NP_001131134
755
84185
S338
T
I
S
I
S
S
A
S
Q
Q
G
L
S
P
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
T540
T
L
S
I
S
S
A
T
E
E
G
H
V
P
W
Honey Bee
Apis mellifera
XP_393918
714
80231
L337
G
R
L
A
T
E
A
L
E
R
G
I
A
T
G
Nematode Worm
Caenorhab. elegans
P51559
943
103128
T368
T
L
S
I
S
S
A
T
Y
D
N
H
R
P
W
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
D340
S
I
T
I
G
A
I
D
H
K
D
L
H
P
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
42.9
96.4
N.A.
92.5
92.6
N.A.
78.2
N.A.
41.2
72.5
N.A.
32.6
44
33.8
N.A.
Protein Similarity:
100
100
58.5
97.8
N.A.
96.4
96.1
N.A.
84.4
N.A.
57.4
84.1
N.A.
45.7
58.7
49.4
N.A.
P-Site Identity:
100
100
66.6
100
N.A.
100
100
N.A.
100
N.A.
60
100
N.A.
60
13.3
53.3
N.A.
P-Site Similarity:
100
100
80
100
N.A.
100
100
N.A.
100
N.A.
73.3
100
N.A.
86.6
46.6
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
85
0
0
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
8
8
0
0
0
0
% D
% Glu:
0
0
0
0
0
8
0
0
16
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
8
0
0
0
8
0
0
0
0
0
85
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
16
8
0
0
% H
% Ile:
0
62
0
93
0
0
8
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% K
% Leu:
0
31
8
0
0
0
0
8
0
0
0
62
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
16
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
93
8
% P
% Gln:
0
0
0
0
0
0
0
0
70
54
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
8
0
0
8
0
0
% R
% Ser:
8
0
85
0
85
85
0
54
0
0
0
0
54
0
0
% S
% Thr:
85
0
8
0
8
0
8
31
0
0
0
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
24
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
85
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _