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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK1
All Species:
17.27
Human Site:
S460
Identified Species:
31.67
UniProt:
P29120
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29120
NP_000430.3
753
84152
S460
A
D
P
R
T
W
R
S
V
P
E
K
K
E
C
Chimpanzee
Pan troglodytes
XP_517645
753
84134
S460
A
D
P
R
T
W
R
S
V
P
E
K
K
E
C
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
T443
A
L
A
Q
N
W
T
T
V
G
P
Q
R
K
C
Dog
Lupus familis
XP_848637
753
84126
S460
A
D
P
R
T
W
T
S
V
P
E
K
K
E
C
Cat
Felis silvestris
Mouse
Mus musculus
P63239
753
84155
N460
A
D
P
R
T
W
R
N
V
P
E
K
K
E
C
Rat
Rattus norvegicus
P28840
752
84102
N460
A
D
P
R
T
W
R
N
V
P
E
K
K
E
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512273
758
84714
A466
A
D
R
S
T
W
R
A
V
P
E
K
K
V
C
Chicken
Gallus gallus
Frog
Xenopus laevis
P29119
783
86425
T441
A
M
A
K
T
W
V
T
V
G
P
Q
R
K
Y
Zebra Danio
Brachydanio rerio
NP_001131134
755
84185
H463
A
D
P
K
V
W
K
H
V
P
E
K
K
Q
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
A662
R
V
A
R
N
W
K
A
V
P
E
Q
Q
R
C
Honey Bee
Apis mellifera
XP_393918
714
80231
N450
L
A
L
Q
V
N
K
N
L
T
W
R
D
V
Q
Nematode Worm
Caenorhab. elegans
P51559
943
103128
T491
N
M
A
K
T
W
K
T
V
P
E
Q
H
I
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
N461
E
M
S
K
T
W
E
N
V
N
A
Q
T
W
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
42.9
96.4
N.A.
92.5
92.6
N.A.
78.2
N.A.
41.2
72.5
N.A.
32.6
44
33.8
N.A.
Protein Similarity:
100
100
58.5
97.8
N.A.
96.4
96.1
N.A.
84.4
N.A.
57.4
84.1
N.A.
45.7
58.7
49.4
N.A.
P-Site Identity:
100
100
26.6
93.3
N.A.
93.3
93.3
N.A.
73.3
N.A.
26.6
66.6
N.A.
40
0
40
N.A.
P-Site Similarity:
100
100
60
93.3
N.A.
100
100
N.A.
80
N.A.
60
86.6
N.A.
66.6
33.3
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
70
8
31
0
0
0
0
16
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
77
% C
% Asp:
0
54
0
0
0
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
8
0
0
0
0
0
8
0
0
0
70
0
0
39
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
0
16
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
0
0
0
31
0
0
31
0
0
0
0
54
54
16
0
% K
% Leu:
8
8
8
0
0
0
0
0
8
0
0
0
0
0
0
% L
% Met:
0
24
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
16
8
0
31
0
8
0
0
0
0
0
% N
% Pro:
0
0
47
0
0
0
0
0
0
70
16
0
0
0
0
% P
% Gln:
0
0
0
16
0
0
0
0
0
0
0
39
8
8
8
% Q
% Arg:
8
0
8
47
0
0
39
0
0
0
0
8
16
8
0
% R
% Ser:
0
0
8
8
0
0
0
24
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
70
0
16
24
0
8
0
0
8
0
0
% T
% Val:
0
8
0
0
16
0
8
0
93
0
0
0
0
16
0
% V
% Trp:
0
0
0
0
0
93
0
0
0
0
8
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _