KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK1
All Species:
11.52
Human Site:
S645
Identified Species:
21.11
UniProt:
P29120
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29120
NP_000430.3
753
84152
S645
E
N
T
L
V
S
K
S
P
S
S
S
S
V
G
Chimpanzee
Pan troglodytes
XP_517645
753
84134
S645
E
N
T
L
V
S
K
S
P
S
S
S
S
V
G
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
H645
A
S
V
C
A
P
C
H
A
S
C
A
T
C
Q
Dog
Lupus familis
XP_848637
753
84126
S645
K
N
P
L
E
S
K
S
P
S
G
S
S
S
G
Cat
Felis silvestris
Mouse
Mus musculus
P63239
753
84155
N645
G
N
L
L
V
P
K
N
S
S
S
S
N
V
E
Rat
Rattus norvegicus
P28840
752
84102
K644
N
G
N
L
L
V
P
K
N
S
S
S
S
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512273
758
84714
E650
S
E
T
P
P
V
S
E
G
P
N
G
Y
N
S
Chicken
Gallus gallus
Frog
Xenopus laevis
P29119
783
86425
S618
S
C
P
Q
G
F
T
S
S
I
Q
N
I
H
Y
Zebra Danio
Brachydanio rerio
NP_001131134
755
84185
P649
E
I
P
N
Q
A
I
P
D
S
P
P
S
T
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
S905
P
V
N
P
Y
S
S
S
P
M
D
H
S
L
L
Honey Bee
Apis mellifera
XP_393918
714
80231
D610
S
V
A
S
W
G
E
D
P
R
G
S
W
T
L
Nematode Worm
Caenorhab. elegans
P51559
943
103128
T818
D
S
S
C
E
T
C
T
A
P
G
P
M
S
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
P667
P
D
S
D
P
N
T
P
K
K
L
S
S
P
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
42.9
96.4
N.A.
92.5
92.6
N.A.
78.2
N.A.
41.2
72.5
N.A.
32.6
44
33.8
N.A.
Protein Similarity:
100
100
58.5
97.8
N.A.
96.4
96.1
N.A.
84.4
N.A.
57.4
84.1
N.A.
45.7
58.7
49.4
N.A.
P-Site Identity:
100
100
6.6
66.6
N.A.
53.3
33.3
N.A.
6.6
N.A.
6.6
20
N.A.
26.6
13.3
0
N.A.
P-Site Similarity:
100
100
26.6
73.3
N.A.
66.6
40
N.A.
13.3
N.A.
13.3
26.6
N.A.
33.3
20
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
8
8
0
0
16
0
0
8
0
0
8
% A
% Cys:
0
8
0
16
0
0
16
0
0
0
8
0
0
8
8
% C
% Asp:
8
8
0
8
0
0
0
8
8
0
8
0
0
0
0
% D
% Glu:
24
8
0
0
16
0
8
8
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
8
0
0
8
8
0
0
8
0
24
8
0
0
24
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
8
0
8
0
% H
% Ile:
0
8
0
0
0
0
8
0
0
8
0
0
8
0
0
% I
% Lys:
8
0
0
0
0
0
31
8
8
8
0
0
0
0
0
% K
% Leu:
0
0
8
39
8
0
0
0
0
0
8
0
0
8
16
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% M
% Asn:
8
31
16
8
0
8
0
8
8
0
8
8
8
8
0
% N
% Pro:
16
0
24
16
16
16
8
16
39
16
8
16
0
8
0
% P
% Gln:
0
0
0
8
8
0
0
0
0
0
8
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% R
% Ser:
24
16
16
8
0
31
16
39
16
54
31
54
54
24
8
% S
% Thr:
0
0
24
0
0
8
16
8
0
0
0
0
8
16
0
% T
% Val:
0
16
8
0
24
16
0
0
0
0
0
0
0
24
8
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _