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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK1
All Species:
15.45
Human Site:
S664
Identified Species:
28.33
UniProt:
P29120
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29120
NP_000430.3
753
84152
S664
E
L
E
E
G
A
P
S
Q
A
M
L
R
L
L
Chimpanzee
Pan troglodytes
XP_517645
753
84134
S664
E
L
E
E
G
A
P
S
E
A
M
L
R
L
L
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
S664
T
D
C
L
S
C
P
S
H
A
S
L
D
P
V
Dog
Lupus familis
XP_848637
753
84126
S664
E
L
V
E
A
A
P
S
E
A
M
L
R
L
L
Cat
Felis silvestris
Mouse
Mus musculus
P63239
753
84155
S664
E
Q
V
Q
G
T
P
S
K
A
M
L
R
L
L
Rat
Rattus norvegicus
P28840
752
84102
P663
D
E
Q
V
Q
G
A
P
S
K
A
M
L
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512273
758
84714
L669
K
L
T
E
Q
T
P
L
D
V
I
R
R
I
L
Chicken
Gallus gallus
Frog
Xenopus laevis
P29119
783
86425
N637
N
I
E
P
L
L
V
N
V
C
V
P
C
H
V
Zebra Danio
Brachydanio rerio
NP_001131134
755
84185
S668
P
E
V
N
S
G
P
S
T
A
N
L
A
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
L924
L
D
D
K
Q
D
P
L
Q
A
E
D
R
R
R
Honey Bee
Apis mellifera
XP_393918
714
80231
N629
E
V
I
H
S
R
I
N
F
P
N
L
I
S
C
Nematode Worm
Caenorhab. elegans
P51559
943
103128
I837
K
G
Y
G
K
G
S
I
G
Y
C
R
P
C
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
I686
Y
F
L
T
I
F
L
I
G
A
T
F
L
V
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
42.9
96.4
N.A.
92.5
92.6
N.A.
78.2
N.A.
41.2
72.5
N.A.
32.6
44
33.8
N.A.
Protein Similarity:
100
100
58.5
97.8
N.A.
96.4
96.1
N.A.
84.4
N.A.
57.4
84.1
N.A.
45.7
58.7
49.4
N.A.
P-Site Identity:
100
93.3
26.6
80
N.A.
66.6
6.6
N.A.
33.3
N.A.
6.6
40
N.A.
26.6
13.3
0
N.A.
P-Site Similarity:
100
100
33.3
86.6
N.A.
80
26.6
N.A.
53.3
N.A.
33.3
40
N.A.
40
26.6
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
24
8
0
0
62
8
0
8
0
0
% A
% Cys:
0
0
8
0
0
8
0
0
0
8
8
0
8
8
16
% C
% Asp:
8
16
8
0
0
8
0
0
8
0
0
8
8
0
0
% D
% Glu:
39
16
24
31
0
0
0
0
16
0
8
0
0
0
0
% E
% Phe:
0
8
0
0
0
8
0
0
8
0
0
8
0
0
0
% F
% Gly:
0
8
0
8
24
24
0
0
16
0
0
0
0
0
0
% G
% His:
0
0
0
8
0
0
0
0
8
0
0
0
0
8
0
% H
% Ile:
0
8
8
0
8
0
8
16
0
0
8
0
8
8
0
% I
% Lys:
16
0
0
8
8
0
0
0
8
8
0
0
0
0
0
% K
% Leu:
8
31
8
8
8
8
8
16
0
0
0
54
16
39
62
% L
% Met:
0
0
0
0
0
0
0
0
0
0
31
8
0
0
0
% M
% Asn:
8
0
0
8
0
0
0
16
0
0
16
0
0
0
0
% N
% Pro:
8
0
0
8
0
0
62
8
0
8
0
8
8
8
0
% P
% Gln:
0
8
8
8
24
0
0
0
16
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
8
0
0
0
0
0
16
47
16
8
% R
% Ser:
0
0
0
0
24
0
8
47
8
0
8
0
0
8
0
% S
% Thr:
8
0
8
8
0
16
0
0
8
0
8
0
0
0
0
% T
% Val:
0
8
24
8
0
0
8
0
8
8
8
0
0
8
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _