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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK1
All Species:
16.36
Human Site:
S688
Identified Species:
30
UniProt:
P29120
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29120
NP_000430.3
753
84152
S688
P
K
Q
S
P
K
K
S
P
S
A
K
L
N
I
Chimpanzee
Pan troglodytes
XP_517645
753
84134
S688
P
K
Q
S
P
K
K
S
P
S
A
K
L
N
I
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
Q688
S
S
R
E
S
P
P
Q
Q
Q
P
P
R
L
P
Dog
Lupus familis
XP_848637
753
84126
S688
P
K
Q
S
P
K
K
S
P
S
A
K
L
N
I
Cat
Felis silvestris
Mouse
Mus musculus
P63239
753
84155
S688
S
K
Q
S
P
K
K
S
P
S
A
K
L
S
I
Rat
Rattus norvegicus
P28840
752
84102
I687
P
S
K
Q
S
S
K
I
P
S
A
K
L
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512273
758
84714
T693
P
N
R
A
P
K
K
T
S
K
E
E
L
R
I
Chicken
Gallus gallus
Frog
Xenopus laevis
P29119
783
86425
P661
I
N
D
C
L
T
C
P
A
H
S
H
Y
N
L
Zebra Danio
Brachydanio rerio
NP_001131134
755
84185
K692
Q
M
P
A
A
P
P
K
S
F
Q
Q
E
R
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
A948
V
P
S
R
V
C
A
A
C
D
R
S
C
L
E
Honey Bee
Apis mellifera
XP_393918
714
80231
V653
T
I
E
G
F
A
L
V
L
H
G
T
R
E
M
Nematode Worm
Caenorhab. elegans
P51559
943
103128
D861
C
E
D
C
S
K
P
D
P
T
L
L
I
D
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
A710
R
R
I
R
R
S
R
A
E
T
Y
E
F
D
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
42.9
96.4
N.A.
92.5
92.6
N.A.
78.2
N.A.
41.2
72.5
N.A.
32.6
44
33.8
N.A.
Protein Similarity:
100
100
58.5
97.8
N.A.
96.4
96.1
N.A.
84.4
N.A.
57.4
84.1
N.A.
45.7
58.7
49.4
N.A.
P-Site Identity:
100
100
0
100
N.A.
86.6
46.6
N.A.
40
N.A.
6.6
6.6
N.A.
0
0
13.3
N.A.
P-Site Similarity:
100
100
6.6
100
N.A.
93.3
66.6
N.A.
66.6
N.A.
20
20
N.A.
6.6
13.3
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
16
8
8
8
16
8
0
39
0
0
0
0
% A
% Cys:
8
0
0
16
0
8
8
0
8
0
0
0
8
0
0
% C
% Asp:
0
0
16
0
0
0
0
8
0
8
0
0
0
16
0
% D
% Glu:
0
8
8
8
0
0
0
0
8
0
8
16
8
8
8
% E
% Phe:
0
0
0
0
8
0
0
0
0
8
0
0
8
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
16
0
8
0
0
0
% H
% Ile:
8
8
8
0
0
0
0
8
0
0
0
0
8
0
54
% I
% Lys:
0
31
8
0
0
47
47
8
0
8
0
39
0
0
0
% K
% Leu:
0
0
0
0
8
0
8
0
8
0
8
8
47
16
8
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
16
0
0
0
0
0
0
0
0
0
0
0
31
0
% N
% Pro:
39
8
8
0
39
16
24
8
47
0
8
8
0
0
8
% P
% Gln:
8
0
31
8
0
0
0
8
8
8
8
8
0
0
0
% Q
% Arg:
8
8
16
16
8
0
8
0
0
0
8
0
16
16
0
% R
% Ser:
16
16
8
31
24
16
0
31
16
39
8
8
0
16
8
% S
% Thr:
8
0
0
0
0
8
0
8
0
16
0
8
0
0
0
% T
% Val:
8
0
0
0
8
0
0
8
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _