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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK1
All Species:
16.97
Human Site:
S719
Identified Species:
31.11
UniProt:
P29120
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29120
NP_000430.3
753
84152
S719
Q
L
K
D
S
E
D
S
L
Y
N
D
Y
V
D
Chimpanzee
Pan troglodytes
XP_517645
753
84134
S719
Q
L
K
D
S
E
D
S
L
Y
N
D
Y
V
D
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
G719
H
L
P
E
V
V
A
G
L
S
C
A
F
I
V
Dog
Lupus familis
XP_848637
753
84126
N719
Q
L
K
D
S
E
D
N
L
Y
S
D
Y
V
D
Cat
Felis silvestris
Mouse
Mus musculus
P63239
753
84155
S719
K
L
E
G
S
E
D
S
L
Y
S
D
Y
V
D
Rat
Rattus norvegicus
P28840
752
84102
S718
Q
L
E
D
S
E
D
S
L
Y
S
D
Y
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512273
758
84714
S724
P
I
R
D
S
E
D
S
L
Y
G
D
D
V
D
Chicken
Gallus gallus
Frog
Xenopus laevis
P29119
783
86425
D692
T
L
K
D
S
S
H
D
Y
V
A
R
T
S
N
Zebra Danio
Brachydanio rerio
NP_001131134
755
84185
N723
A
S
Q
N
G
L
F
N
D
Y
S
D
N
F
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
E979
Q
L
R
K
I
L
N
E
T
F
C
Y
A
Y
V
Honey Bee
Apis mellifera
XP_393918
714
80231
D684
R
I
R
N
I
N
D
D
R
S
M
K
S
M
F
Nematode Worm
Caenorhab. elegans
P51559
943
103128
A892
I
A
A
C
G
I
C
A
C
K
K
C
A
S
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
V741
G
I
T
E
P
E
E
V
E
D
F
D
F
D
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
42.9
96.4
N.A.
92.5
92.6
N.A.
78.2
N.A.
41.2
72.5
N.A.
32.6
44
33.8
N.A.
Protein Similarity:
100
100
58.5
97.8
N.A.
96.4
96.1
N.A.
84.4
N.A.
57.4
84.1
N.A.
45.7
58.7
49.4
N.A.
P-Site Identity:
100
100
13.3
86.6
N.A.
73.3
86.6
N.A.
66.6
N.A.
26.6
13.3
N.A.
13.3
6.6
0
N.A.
P-Site Similarity:
100
100
33.3
100
N.A.
93.3
100
N.A.
80
N.A.
33.3
40
N.A.
33.3
40
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
0
0
0
8
8
0
0
8
8
16
0
0
% A
% Cys:
0
0
0
8
0
0
8
0
8
0
16
8
0
0
0
% C
% Asp:
0
0
0
47
0
0
54
16
8
8
0
62
8
8
47
% D
% Glu:
0
0
16
16
0
54
8
8
8
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
8
0
0
8
8
0
16
8
8
% F
% Gly:
8
0
0
8
16
0
0
8
0
0
8
0
0
0
0
% G
% His:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
8
24
0
0
16
8
0
0
0
0
0
0
0
8
0
% I
% Lys:
8
0
31
8
0
0
0
0
0
8
8
8
0
0
0
% K
% Leu:
0
62
0
0
0
16
0
0
54
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% M
% Asn:
0
0
0
16
0
8
8
16
0
0
16
0
8
0
8
% N
% Pro:
8
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
39
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
24
0
0
0
0
0
8
0
0
8
0
0
0
% R
% Ser:
0
8
0
0
54
8
0
39
0
16
31
0
8
16
0
% S
% Thr:
8
0
8
0
0
0
0
0
8
0
0
0
8
0
0
% T
% Val:
0
0
0
0
8
8
0
8
0
8
0
0
0
47
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
54
0
8
39
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _