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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK1 All Species: 16.97
Human Site: S719 Identified Species: 31.11
UniProt: P29120 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29120 NP_000430.3 753 84152 S719 Q L K D S E D S L Y N D Y V D
Chimpanzee Pan troglodytes XP_517645 753 84134 S719 Q L K D S E D S L Y N D Y V D
Rhesus Macaque Macaca mulatta XP_001094068 794 86687 G719 H L P E V V A G L S C A F I V
Dog Lupus familis XP_848637 753 84126 N719 Q L K D S E D N L Y S D Y V D
Cat Felis silvestris
Mouse Mus musculus P63239 753 84155 S719 K L E G S E D S L Y S D Y V D
Rat Rattus norvegicus P28840 752 84102 S718 Q L E D S E D S L Y S D Y V D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512273 758 84714 S724 P I R D S E D S L Y G D D V D
Chicken Gallus gallus
Frog Xenopus laevis P29119 783 86425 D692 T L K D S S H D Y V A R T S N
Zebra Danio Brachydanio rerio NP_001131134 755 84185 N723 A S Q N G L F N D Y S D N F Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P30430 1101 120975 E979 Q L R K I L N E T F C Y A Y V
Honey Bee Apis mellifera XP_393918 714 80231 D684 R I R N I N D D R S M K S M F
Nematode Worm Caenorhab. elegans P51559 943 103128 A892 I A A C G I C A C K K C A S E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 V741 G I T E P E E V E D F D F D L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 42.9 96.4 N.A. 92.5 92.6 N.A. 78.2 N.A. 41.2 72.5 N.A. 32.6 44 33.8 N.A.
Protein Similarity: 100 100 58.5 97.8 N.A. 96.4 96.1 N.A. 84.4 N.A. 57.4 84.1 N.A. 45.7 58.7 49.4 N.A.
P-Site Identity: 100 100 13.3 86.6 N.A. 73.3 86.6 N.A. 66.6 N.A. 26.6 13.3 N.A. 13.3 6.6 0 N.A.
P-Site Similarity: 100 100 33.3 100 N.A. 93.3 100 N.A. 80 N.A. 33.3 40 N.A. 33.3 40 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 49.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 0 0 8 8 0 0 8 8 16 0 0 % A
% Cys: 0 0 0 8 0 0 8 0 8 0 16 8 0 0 0 % C
% Asp: 0 0 0 47 0 0 54 16 8 8 0 62 8 8 47 % D
% Glu: 0 0 16 16 0 54 8 8 8 0 0 0 0 0 8 % E
% Phe: 0 0 0 0 0 0 8 0 0 8 8 0 16 8 8 % F
% Gly: 8 0 0 8 16 0 0 8 0 0 8 0 0 0 0 % G
% His: 8 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 8 24 0 0 16 8 0 0 0 0 0 0 0 8 0 % I
% Lys: 8 0 31 8 0 0 0 0 0 8 8 8 0 0 0 % K
% Leu: 0 62 0 0 0 16 0 0 54 0 0 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % M
% Asn: 0 0 0 16 0 8 8 16 0 0 16 0 8 0 8 % N
% Pro: 8 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 39 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 8 0 24 0 0 0 0 0 8 0 0 8 0 0 0 % R
% Ser: 0 8 0 0 54 8 0 39 0 16 31 0 8 16 0 % S
% Thr: 8 0 8 0 0 0 0 0 8 0 0 0 8 0 0 % T
% Val: 0 0 0 0 8 8 0 8 0 8 0 0 0 47 16 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 54 0 8 39 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _