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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK1
All Species:
37.88
Human Site:
T594
Identified Species:
69.44
UniProt:
P29120
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29120
NP_000430.3
753
84152
T594
W
K
L
I
L
H
G
T
S
S
Q
P
E
H
M
Chimpanzee
Pan troglodytes
XP_517645
753
84134
T594
W
K
L
I
L
H
G
T
S
S
Q
P
E
H
M
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
Y571
T
K
F
T
L
V
L
Y
G
T
A
P
E
G
L
Dog
Lupus familis
XP_848637
753
84126
T594
W
K
L
I
L
H
G
T
S
S
Q
P
E
H
M
Cat
Felis silvestris
Mouse
Mus musculus
P63239
753
84155
T594
W
K
L
I
L
H
G
T
S
S
Q
P
E
H
M
Rat
Rattus norvegicus
P28840
752
84102
T594
W
K
L
I
L
H
G
T
S
S
Q
P
E
H
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512273
758
84714
T600
W
R
L
I
L
H
G
T
S
S
Q
P
E
H
M
Chicken
Gallus gallus
Frog
Xenopus laevis
P29119
783
86425
T571
F
V
L
V
L
Y
G
T
A
S
E
G
L
S
R
Zebra Danio
Brachydanio rerio
NP_001131134
755
84185
T597
W
K
L
I
L
H
G
T
S
E
K
P
E
H
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
T790
M
I
F
Y
G
T
E
T
P
A
Q
P
D
D
V
Honey Bee
Apis mellifera
XP_393918
714
80231
S564
I
E
V
S
L
E
Y
S
V
R
G
S
I
Q
I
Nematode Worm
Caenorhab. elegans
P51559
943
103128
T626
W
T
L
L
L
Y
G
T
A
D
P
A
Q
S
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
A615
D
K
E
E
V
E
P
A
A
T
E
S
T
V
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
42.9
96.4
N.A.
92.5
92.6
N.A.
78.2
N.A.
41.2
72.5
N.A.
32.6
44
33.8
N.A.
Protein Similarity:
100
100
58.5
97.8
N.A.
96.4
96.1
N.A.
84.4
N.A.
57.4
84.1
N.A.
45.7
58.7
49.4
N.A.
P-Site Identity:
100
100
26.6
100
N.A.
100
100
N.A.
93.3
N.A.
33.3
86.6
N.A.
20
6.6
33.3
N.A.
P-Site Similarity:
100
100
40
100
N.A.
100
100
N.A.
100
N.A.
66.6
93.3
N.A.
40
33.3
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
24
8
8
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
8
0
0
8
8
0
% D
% Glu:
0
8
8
8
0
16
8
0
0
8
16
0
62
0
0
% E
% Phe:
8
0
16
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
70
0
8
0
8
8
0
8
8
% G
% His:
0
0
0
0
0
54
0
0
0
0
0
0
0
54
0
% H
% Ile:
8
8
0
54
0
0
0
0
0
0
0
0
8
0
8
% I
% Lys:
0
62
0
0
0
0
0
0
0
0
8
0
0
0
0
% K
% Leu:
0
0
70
8
85
0
8
0
0
0
0
0
8
0
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
8
0
8
70
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
54
0
8
8
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
8
% R
% Ser:
0
0
0
8
0
0
0
8
54
54
0
16
0
16
8
% S
% Thr:
8
8
0
8
0
8
0
77
0
16
0
0
8
0
0
% T
% Val:
0
8
8
8
8
8
0
0
8
0
0
0
0
8
8
% V
% Trp:
62
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
16
8
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _