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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK1
All Species:
27.27
Human Site:
Y178
Identified Species:
50
UniProt:
P29120
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29120
NP_000430.3
753
84152
Y178
E
W
N
H
T
D
I
Y
A
N
Y
D
P
E
A
Chimpanzee
Pan troglodytes
XP_517645
753
84134
Y178
E
W
N
H
T
D
I
Y
A
N
Y
D
P
E
A
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
Y167
H
P
D
L
A
G
N
Y
D
P
G
A
S
F
D
Dog
Lupus familis
XP_848637
753
84126
Y178
E
W
N
H
T
D
I
Y
A
N
Y
D
P
E
A
Cat
Felis silvestris
Mouse
Mus musculus
P63239
753
84155
Y178
E
W
N
H
T
D
I
Y
A
N
Y
D
P
E
A
Rat
Rattus norvegicus
P28840
752
84102
Y178
E
W
N
H
T
D
I
Y
A
N
Y
D
P
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512273
758
84714
Y184
E
W
N
H
T
D
I
Y
A
N
Y
D
P
D
A
Chicken
Gallus gallus
Frog
Xenopus laevis
P29119
783
86425
P167
D
L
Q
A
N
Y
D
P
A
A
S
Y
D
V
N
Zebra Danio
Brachydanio rerio
NP_001131134
755
84185
Y181
E
W
N
H
T
D
I
Y
P
N
Y
D
P
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
Q383
E
S
D
H
P
D
I
Q
D
N
Y
D
P
K
A
Honey Bee
Apis mellifera
XP_393918
714
80231
R182
W
D
Q
E
W
Y
L
R
D
T
R
S
N
K
A
Nematode Worm
Caenorhab. elegans
P51559
943
103128
A213
Q
R
D
H
P
D
L
A
A
N
Y
D
P
L
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
K186
D
Y
E
N
E
D
L
K
D
N
F
C
A
E
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
42.9
96.4
N.A.
92.5
92.6
N.A.
78.2
N.A.
41.2
72.5
N.A.
32.6
44
33.8
N.A.
Protein Similarity:
100
100
58.5
97.8
N.A.
96.4
96.1
N.A.
84.4
N.A.
57.4
84.1
N.A.
45.7
58.7
49.4
N.A.
P-Site Identity:
100
100
6.6
100
N.A.
100
100
N.A.
93.3
N.A.
6.6
86.6
N.A.
60
6.6
53.3
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
100
100
N.A.
100
N.A.
13.3
86.6
N.A.
73.3
20
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
0
8
62
8
0
8
8
8
77
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
16
8
24
0
0
77
8
0
31
0
0
70
8
8
8
% D
% Glu:
62
0
8
8
8
0
0
0
0
0
0
0
0
47
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% F
% Gly:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
8
% G
% His:
8
0
0
70
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
62
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
0
0
0
16
0
% K
% Leu:
0
8
0
8
0
0
24
0
0
0
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
54
8
8
0
8
0
0
77
0
0
8
0
8
% N
% Pro:
0
8
0
0
16
0
0
8
8
8
0
0
70
0
0
% P
% Gln:
8
0
16
0
0
0
0
8
0
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
8
0
0
8
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
0
0
0
0
8
8
8
0
0
% S
% Thr:
0
0
0
0
54
0
0
0
0
8
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
8
54
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
16
0
62
0
0
70
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _