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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK1
All Species:
25.45
Human Site:
Y701
Identified Species:
46.67
UniProt:
P29120
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29120
NP_000430.3
753
84152
Y701
N
I
P
Y
E
N
F
Y
E
A
L
E
K
L
N
Chimpanzee
Pan troglodytes
XP_517645
753
84134
Y701
N
I
P
Y
E
N
F
Y
E
A
L
E
K
L
N
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
G701
L
P
P
E
M
E
A
G
P
R
L
R
A
G
L
Dog
Lupus familis
XP_848637
753
84126
Y701
N
I
P
Y
E
N
F
Y
E
A
L
E
K
L
N
Cat
Felis silvestris
Mouse
Mus musculus
P63239
753
84155
Y701
S
I
P
Y
E
S
F
Y
E
A
L
E
K
L
N
Rat
Rattus norvegicus
P28840
752
84102
Y700
S
V
P
Y
E
G
L
Y
E
A
L
E
K
L
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512273
758
84714
Y706
R
I
L
H
R
L
F
Y
Q
A
L
E
R
L
N
Chicken
Gallus gallus
Frog
Xenopus laevis
P29119
783
86425
T674
N
L
L
D
Y
S
C
T
H
Q
T
Q
R
S
R
Zebra Danio
Brachydanio rerio
NP_001131134
755
84185
Y705
R
I
P
P
Q
K
L
Y
Q
A
L
D
L
L
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
A961
L
E
C
Y
G
A
L
A
S
Q
C
S
T
C
S
Honey Bee
Apis mellifera
XP_393918
714
80231
N666
E
M
P
E
Y
R
K
N
G
P
R
I
Y
N
Q
Nematode Worm
Caenorhab. elegans
P51559
943
103128
F874
D
S
N
K
S
S
G
F
G
L
M
F
W
I
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
E723
D
I
I
D
T
D
S
E
Y
D
S
T
L
D
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
42.9
96.4
N.A.
92.5
92.6
N.A.
78.2
N.A.
41.2
72.5
N.A.
32.6
44
33.8
N.A.
Protein Similarity:
100
100
58.5
97.8
N.A.
96.4
96.1
N.A.
84.4
N.A.
57.4
84.1
N.A.
45.7
58.7
49.4
N.A.
P-Site Identity:
100
100
13.3
100
N.A.
86.6
73.3
N.A.
53.3
N.A.
6.6
46.6
N.A.
6.6
6.6
0
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
100
86.6
N.A.
73.3
N.A.
33.3
66.6
N.A.
13.3
13.3
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
8
8
0
54
0
0
8
0
0
% A
% Cys:
0
0
8
0
0
0
8
0
0
0
8
0
0
8
0
% C
% Asp:
16
0
0
16
0
8
0
0
0
8
0
8
0
8
0
% D
% Glu:
8
8
0
16
39
8
0
8
39
0
0
47
0
0
0
% E
% Phe:
0
0
0
0
0
0
39
8
0
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
8
8
8
8
16
0
0
0
0
8
0
% G
% His:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
54
8
0
0
0
0
0
0
0
0
8
0
8
0
% I
% Lys:
0
0
0
8
0
8
8
0
0
0
0
0
39
0
0
% K
% Leu:
16
8
16
0
0
8
24
0
0
8
62
0
16
54
8
% L
% Met:
0
8
0
0
8
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
31
0
8
0
0
24
0
8
0
0
0
0
0
8
62
% N
% Pro:
0
8
62
8
0
0
0
0
8
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
16
16
0
8
0
0
8
% Q
% Arg:
16
0
0
0
8
8
0
0
0
8
8
8
16
0
8
% R
% Ser:
16
8
0
0
8
24
8
0
8
0
8
8
0
8
8
% S
% Thr:
0
0
0
0
8
0
0
8
0
0
8
8
8
0
0
% T
% Val:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
47
16
0
0
54
8
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _