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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK1
All Species:
19.7
Human Site:
Y724
Identified Species:
36.11
UniProt:
P29120
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29120
NP_000430.3
753
84152
Y724
E
D
S
L
Y
N
D
Y
V
D
V
F
Y
N
T
Chimpanzee
Pan troglodytes
XP_517645
753
84134
Y724
E
D
S
L
Y
N
D
Y
V
D
V
F
Y
N
T
Rhesus Macaque
Macaca mulatta
XP_001094068
794
86687
F724
V
A
G
L
S
C
A
F
I
V
L
V
F
V
T
Dog
Lupus familis
XP_848637
753
84126
Y724
E
D
N
L
Y
S
D
Y
V
D
V
F
Y
N
T
Cat
Felis silvestris
Mouse
Mus musculus
P63239
753
84155
Y724
E
D
S
L
Y
S
D
Y
V
D
V
F
Y
N
T
Rat
Rattus norvegicus
P28840
752
84102
Y723
E
D
S
L
Y
S
D
Y
V
D
V
F
Y
N
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512273
758
84714
D729
E
D
S
L
Y
G
D
D
V
D
V
F
Y
N
T
Chicken
Gallus gallus
Frog
Xenopus laevis
P29119
783
86425
T697
S
H
D
Y
V
A
R
T
S
N
L
P
F
I
V
Zebra Danio
Brachydanio rerio
NP_001131134
755
84185
N728
L
F
N
D
Y
S
D
N
F
Y
R
A
Q
P
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
A984
L
N
E
T
F
C
Y
A
Y
V
V
R
S
T
G
Honey Bee
Apis mellifera
XP_393918
714
80231
S689
N
D
D
R
S
M
K
S
M
F
E
R
K
L
G
Nematode Worm
Caenorhab. elegans
P51559
943
103128
A897
I
C
A
C
K
K
C
A
S
E
T
K
S
S
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
F746
E
E
V
E
D
F
D
F
D
L
S
D
E
D
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
42.9
96.4
N.A.
92.5
92.6
N.A.
78.2
N.A.
41.2
72.5
N.A.
32.6
44
33.8
N.A.
Protein Similarity:
100
100
58.5
97.8
N.A.
96.4
96.1
N.A.
84.4
N.A.
57.4
84.1
N.A.
45.7
58.7
49.4
N.A.
P-Site Identity:
100
100
13.3
86.6
N.A.
93.3
93.3
N.A.
86.6
N.A.
0
13.3
N.A.
6.6
6.6
0
N.A.
P-Site Similarity:
100
100
40
100
N.A.
100
100
N.A.
86.6
N.A.
20
26.6
N.A.
20
13.3
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
49.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
8
8
16
0
0
0
8
0
0
0
% A
% Cys:
0
8
0
8
0
16
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
54
16
8
8
0
62
8
8
47
0
8
0
8
0
% D
% Glu:
54
8
8
8
0
0
0
0
0
8
8
0
8
0
0
% E
% Phe:
0
8
0
0
8
8
0
16
8
8
0
47
16
0
0
% F
% Gly:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
16
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
8
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
8
8
8
0
0
0
0
8
8
0
0
% K
% Leu:
16
0
0
54
0
0
0
0
0
8
16
0
0
8
0
% L
% Met:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
0
% M
% Asn:
8
8
16
0
0
16
0
8
0
8
0
0
0
47
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
8
0
0
8
0
0
0
8
16
0
0
0
% R
% Ser:
8
0
39
0
16
31
0
8
16
0
8
0
16
8
0
% S
% Thr:
0
0
0
8
0
0
0
8
0
0
8
0
0
8
54
% T
% Val:
8
0
8
0
8
0
0
0
47
16
54
8
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
54
0
8
39
8
8
0
0
47
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _