Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK6 All Species: 14.85
Human Site: S221 Identified Species: 29.7
UniProt: P29122 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29122 NP_002561.1 969 106420 S221 D L A P N Y D S Y A S Y D V N
Chimpanzee Pan troglodytes XP_001146976 986 108574 S238 D L A P N Y D S Y A S Y D V N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_545820 1355 149403 S607 D L A P N Y D S Y A S Y D V N
Cat Felis silvestris
Mouse Mus musculus Q04592 1877 209270 A189 D L M Q N Y D A L A S C D V N
Rat Rattus norvegicus Q63415 937 104035 S202 D L A P N Y D S Y A S Y D V N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507677 642 72067
Chicken Gallus gallus XP_413892 919 101787 P189 D L L Q N Y D P L A S Y D V N
Frog Xenopus laevis P29119 783 86425 L75 R A V M K R S L T P K R T R Q
Zebra Danio Brachydanio rerio NP_001077298 917 101996 N192 D L I Q N Y D N E A S Y D V N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P30432 1679 183351 Y431 H P D L A Q N Y D P E A S F D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P51559 943 103128 Y216 H P D L A A N Y D P L A S T D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 L106 D L F P R N D L F K R L P V P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.3 N.A. 64.5 N.A. 31.8 89.7 N.A. 58.9 69.2 40.7 55.9 N.A. 30.4 N.A. 35.5 N.A.
Protein Similarity: 100 91.5 N.A. 67.4 N.A. 39.4 92.7 N.A. 62.5 78.6 52 68.2 N.A. 40 N.A. 48.8 N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 66.6 100 N.A. 0 73.3 0 73.3 N.A. 0 N.A. 0 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 73.3 100 N.A. 0 73.3 0 80 N.A. 13.3 N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 34 0 17 9 0 9 0 59 0 17 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % C
% Asp: 67 0 17 0 0 0 67 0 17 0 0 0 59 0 17 % D
% Glu: 0 0 0 0 0 0 0 0 9 0 9 0 0 0 0 % E
% Phe: 0 0 9 0 0 0 0 0 9 0 0 0 0 9 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 9 0 0 0 0 9 9 0 0 0 0 % K
% Leu: 0 67 9 17 0 0 0 17 17 0 9 9 0 0 0 % L
% Met: 0 0 9 9 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 59 9 17 9 0 0 0 0 0 0 59 % N
% Pro: 0 17 0 42 0 0 0 9 0 25 0 0 9 0 9 % P
% Gln: 0 0 0 25 0 9 0 0 0 0 0 0 0 0 9 % Q
% Arg: 9 0 0 0 9 9 0 0 0 0 9 9 0 9 0 % R
% Ser: 0 0 0 0 0 0 9 34 0 0 59 0 17 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 9 0 0 0 9 9 0 % T
% Val: 0 0 9 0 0 0 0 0 0 0 0 0 0 67 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 59 0 17 34 0 0 50 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _