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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK6
All Species:
28.18
Human Site:
S291
Identified Species:
56.36
UniProt:
P29122
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29122
NP_002561.1
969
106420
S291
T
D
V
V
E
A
K
S
L
G
I
R
P
N
Y
Chimpanzee
Pan troglodytes
XP_001146976
986
108574
S308
T
D
V
V
E
A
K
S
L
G
I
R
P
N
Y
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_545820
1355
149403
S677
T
D
V
V
E
A
K
S
L
G
I
R
P
N
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q04592
1877
209270
S259
T
D
M
V
E
A
K
S
V
S
Y
N
P
Q
H
Rat
Rattus norvegicus
Q63415
937
104035
S272
T
D
V
V
E
A
K
S
L
G
I
R
P
N
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507677
642
72067
Chicken
Gallus gallus
XP_413892
919
101787
S259
T
D
V
V
E
A
K
S
L
G
I
R
P
D
Y
Frog
Xenopus laevis
P29119
783
86425
I145
Q
G
F
T
G
K
G
I
V
V
S
I
L
D
D
Zebra Danio
Brachydanio rerio
NP_001077298
917
101996
S262
T
D
M
V
E
A
K
S
L
S
L
H
P
Q
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30432
1679
183351
A501
N
D
V
V
E
A
Q
A
L
S
L
N
P
S
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
S286
S
D
S
V
E
A
A
S
L
S
L
N
Q
D
H
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
D176
V
V
A
A
I
V
D
D
G
L
D
Y
E
N
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.3
N.A.
64.5
N.A.
31.8
89.7
N.A.
58.9
69.2
40.7
55.9
N.A.
30.4
N.A.
35.5
N.A.
Protein Similarity:
100
91.5
N.A.
67.4
N.A.
39.4
92.7
N.A.
62.5
78.6
52
68.2
N.A.
40
N.A.
48.8
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
53.3
100
N.A.
0
93.3
0
60
N.A.
46.6
N.A.
40
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
73.3
100
N.A.
0
100
13.3
80
N.A.
80
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
42.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
9
0
75
9
9
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
75
0
0
0
0
9
9
0
0
9
0
0
25
9
% D
% Glu:
0
0
0
0
75
0
0
0
0
0
0
0
9
0
9
% E
% Phe:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
9
0
9
0
9
42
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
34
% H
% Ile:
0
0
0
0
9
0
0
9
0
0
42
9
0
0
0
% I
% Lys:
0
0
0
0
0
9
59
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
67
9
25
0
9
0
0
% L
% Met:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
0
0
0
0
0
0
0
0
0
0
25
0
42
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
67
0
0
% P
% Gln:
9
0
0
0
0
0
9
0
0
0
0
0
9
17
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
42
0
0
0
% R
% Ser:
9
0
9
0
0
0
0
67
0
34
9
0
0
9
0
% S
% Thr:
59
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
9
9
50
75
0
9
0
0
17
9
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
42
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _