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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK6
All Species:
29.09
Human Site:
S453
Identified Species:
58.18
UniProt:
P29122
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29122
NP_002561.1
969
106420
S453
Q
H
L
L
V
K
T
S
R
P
A
H
L
K
A
Chimpanzee
Pan troglodytes
XP_001146976
986
108574
S470
Q
H
L
L
V
K
T
S
R
P
A
H
L
K
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_545820
1355
149403
S839
Q
H
L
L
V
K
T
S
R
P
A
H
L
K
A
Cat
Felis silvestris
Mouse
Mus musculus
Q04592
1877
209270
S421
Q
H
V
I
V
R
T
S
R
A
G
H
L
N
A
Rat
Rattus norvegicus
Q63415
937
104035
S434
Q
H
L
L
V
K
T
S
R
P
A
H
L
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507677
642
72067
A165
T
R
C
A
G
E
V
A
A
S
A
N
N
S
Y
Chicken
Gallus gallus
XP_413892
919
101787
S421
Q
H
L
L
V
R
T
S
R
P
V
H
L
R
A
Frog
Xenopus laevis
P29119
783
86425
Y306
D
S
C
N
C
D
G
Y
T
N
S
I
Y
T
L
Zebra Danio
Brachydanio rerio
NP_001077298
917
101996
S424
Q
H
I
V
V
K
T
S
R
A
G
H
L
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30432
1679
183351
S670
Q
Y
L
V
V
Y
T
S
R
P
A
P
L
E
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
A448
Q
H
L
V
L
R
T
A
N
W
K
P
L
E
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
G337
S
I
Y
S
I
T
I
G
A
I
D
H
K
D
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.3
N.A.
64.5
N.A.
31.8
89.7
N.A.
58.9
69.2
40.7
55.9
N.A.
30.4
N.A.
35.5
N.A.
Protein Similarity:
100
91.5
N.A.
67.4
N.A.
39.4
92.7
N.A.
62.5
78.6
52
68.2
N.A.
40
N.A.
48.8
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
60
100
N.A.
6.6
80
0
66.6
N.A.
60
N.A.
33.3
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
80
100
N.A.
26.6
93.3
6.6
80
N.A.
80
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
42.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
0
17
17
17
50
0
0
0
59
% A
% Cys:
0
0
17
0
9
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
9
0
0
0
0
9
0
0
9
0
% D
% Glu:
0
0
0
0
0
9
0
0
0
0
0
0
0
17
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
9
0
9
9
0
0
17
0
0
0
0
% G
% His:
0
67
0
0
0
0
0
0
0
0
0
67
0
0
0
% H
% Ile:
0
9
9
9
9
0
9
0
0
9
0
9
0
0
0
% I
% Lys:
0
0
0
0
0
42
0
0
0
0
9
0
9
34
9
% K
% Leu:
0
0
59
42
9
0
0
0
0
0
0
0
75
0
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
0
9
9
0
9
9
9
9
% N
% Pro:
0
0
0
0
0
0
0
0
0
50
0
17
0
0
0
% P
% Gln:
75
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
0
0
0
25
0
0
67
0
0
0
0
9
0
% R
% Ser:
9
9
0
9
0
0
0
67
0
9
9
0
0
17
0
% S
% Thr:
9
0
0
0
0
9
75
0
9
0
0
0
0
9
0
% T
% Val:
0
0
9
25
67
0
9
0
0
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% W
% Tyr:
0
9
9
0
0
9
0
9
0
0
0
0
9
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _