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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TPP2 All Species: 38.48
Human Site: S368 Identified Species: 65.13
UniProt: P29144 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29144 NP_003282.2 1249 138350 S368 G N N G P C L S T V G C P G G
Chimpanzee Pan troglodytes XP_001151602 1249 138350 S368 G N N G P C L S T V G C P G G
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q64514 1262 139860 S368 G N N G P C L S T V G C P G G
Rat Rattus norvegicus Q64560 1249 138274 S368 G N N G P C L S T V G C P G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513544 1367 152093 S473 G N N G P C L S T V G C P G G
Chicken Gallus gallus XP_425591 1248 138209 S367 G N N G P C L S T V G C P G G
Frog Xenopus laevis NP_001085380 1261 139671 T367 G N N G P C L T T V G C P G G
Zebra Danio Brachydanio rerio XP_693179 595 63935
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V6K1 1441 158719 T468 N H G P A L C T V G T P P D I
Honey Bee Apis mellifera XP_395521 1450 161968 T371 N L G P A L C T I G T P P D I
Nematode Worm Caenorhab. elegans Q09541 1374 151070 S418 G N Q G P A L S T V G A P G G
Sea Urchin Strong. purpuratus XP_788834 1215 133209 S368 G N N G P A L S T V G C P G G
Poplar Tree Populus trichocarpa XP_002318216 1299 143140 T397 N S G P A L S T V G A P G G T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_193817 1380 152349 T477 N S G P A L T T V G A P G G T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. N.A. N.A. 95.3 96.8 N.A. 81.2 86 80.4 37.7 N.A. 34 41.3 35 54.7
Protein Similarity: 100 99.7 N.A. N.A. N.A. 97.4 98.7 N.A. 86.6 94.6 91.3 43.1 N.A. 53 59.2 53.4 71.6
P-Site Identity: 100 100 N.A. N.A. N.A. 100 100 N.A. 100 100 93.3 0 N.A. 6.6 6.6 80 93.3
P-Site Similarity: 100 100 N.A. N.A. N.A. 100 100 N.A. 100 100 100 0 N.A. 20 13.3 80 93.3
Percent
Protein Identity: 38 N.A. N.A. 37.4 N.A. N.A.
Protein Similarity: 56.9 N.A. N.A. 54.1 N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 29 15 0 0 0 0 15 8 0 0 0 % A
% Cys: 0 0 0 0 0 50 15 0 0 0 0 58 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 15 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 65 0 29 65 0 0 0 0 0 29 65 0 15 79 65 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 15 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 8 0 0 0 29 65 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 29 65 58 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 29 65 0 0 0 0 0 0 29 79 0 0 % P
% Gln: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 15 0 0 0 0 8 58 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 8 36 65 0 15 0 0 0 15 % T
% Val: 0 0 0 0 0 0 0 0 22 65 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _