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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IMPA1 All Species: 44.85
Human Site: T82 Identified Species: 70.48
UniProt: P29218 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29218 NP_001138350.1 277 30189 T82 A G E K S I L T D N P T W I I
Chimpanzee Pan troglodytes XP_001168821 277 30156 T82 A G E K S I L T D N P T W I I
Rhesus Macaque Macaca mulatta XP_001092596 277 30251 T82 A G E K S I L T N N P T W I I
Dog Lupus familis XP_535114 277 30225 T82 A G E K S I L T D S P T W I I
Cat Felis silvestris
Mouse Mus musculus O55023 277 30418 T82 A G E K T V F T E S P T W F I
Rat Rattus norvegicus P97697 277 30493 T82 S G E K T V F T E Q P T W I I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508686 235 25995 I67 F P T V A V S I G F A V K Q E
Chicken Gallus gallus XP_418310 278 30123 T82 A G E G S I L T D N P T W I I
Frog Xenopus laevis P29219 285 30711 T85 A G A G S T L T D N P T W I I
Zebra Danio Brachydanio rerio NP_001002745 282 30560 T82 A G E P C V L T E N P T W I V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_393191 272 29815 T81 L G S K I E L T E A P T W I I
Nematode Worm Caenorhab. elegans Q19420 285 30962 T88 G G A K I E W T D A P T W I I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M8S8 271 29103 T83 A F G V T E L T D E P T W I V
Baker's Yeast Sacchar. cerevisiae Q05533 292 32074 T86 V K G V T K I T N G P T F I V
Red Bread Mold Neurospora crassa P11634 340 37305 H107 T R P Y L V T H T T P T W V V
Conservation
Percent
Protein Identity: 100 99.6 97.8 90.2 N.A. 86.2 84.8 N.A. 46.5 82 74.3 65.9 N.A. N.A. 49 45.6 N.A.
Protein Similarity: 100 100 99.6 95.6 N.A. 94.2 93.8 N.A. 64.2 92.8 88.7 82.6 N.A. N.A. 67.1 60.3 N.A.
P-Site Identity: 100 100 93.3 93.3 N.A. 60 60 N.A. 0 93.3 80 66.6 N.A. N.A. 60 60 N.A.
P-Site Similarity: 100 100 100 100 N.A. 86.6 86.6 N.A. 13.3 93.3 80 86.6 N.A. N.A. 66.6 60 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 40.7 36.3 30.5
Protein Similarity: N.A. N.A. N.A. 61 55.1 46.4
P-Site Identity: N.A. N.A. N.A. 53.3 26.6 20
P-Site Similarity: N.A. N.A. N.A. 66.6 60 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 60 0 14 0 7 0 0 0 0 14 7 0 0 0 0 % A
% Cys: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 47 0 0 0 0 0 0 % D
% Glu: 0 0 54 0 0 20 0 0 27 7 0 0 0 0 7 % E
% Phe: 7 7 0 0 0 0 14 0 0 7 0 0 7 7 0 % F
% Gly: 7 74 14 14 0 0 0 0 7 7 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 14 34 7 7 0 0 0 0 0 80 67 % I
% Lys: 0 7 0 54 0 7 0 0 0 0 0 0 7 0 0 % K
% Leu: 7 0 0 0 7 0 60 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 14 40 0 0 0 0 0 % N
% Pro: 0 7 7 7 0 0 0 0 0 0 94 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 7 0 0 0 7 0 % Q
% Arg: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 7 0 7 0 40 0 7 0 0 14 0 0 0 0 0 % S
% Thr: 7 0 7 0 27 7 7 87 7 7 0 94 0 0 0 % T
% Val: 7 0 0 20 0 34 0 0 0 0 0 7 0 7 27 % V
% Trp: 0 0 0 0 0 0 7 0 0 0 0 0 87 0 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _