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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TKT
All Species:
39.7
Human Site:
S345
Identified Species:
67.18
UniProt:
P29401
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29401
NP_001055.1
623
67878
S345
L
D
G
D
T
K
N
S
T
F
S
E
I
F
K
Chimpanzee
Pan troglodytes
Q5R1W6
623
67821
S345
L
D
G
D
T
K
N
S
T
F
S
E
I
F
K
Rhesus Macaque
Macaca mulatta
XP_001095403
703
76522
S426
L
S
G
D
T
M
N
S
T
F
S
E
I
F
R
Dog
Lupus familis
XP_533792
619
67627
T349
S
V
A
V
G
C
A
T
R
N
R
T
V
P
F
Cat
Felis silvestris
Mouse
Mus musculus
P40142
623
67612
S345
L
D
G
D
T
K
N
S
T
F
S
E
L
F
K
Rat
Rattus norvegicus
P50137
623
67625
S345
L
D
G
D
T
K
N
S
T
F
S
E
L
F
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508404
725
77819
S447
L
D
G
D
T
K
N
S
T
F
S
E
L
F
K
Chicken
Gallus gallus
XP_414333
627
68436
S345
L
D
G
D
T
K
N
S
T
F
S
E
L
F
K
Frog
Xenopus laevis
NP_001083312
627
67992
S345
L
D
G
D
T
K
N
S
T
F
S
E
L
F
K
Zebra Danio
Brachydanio rerio
XP_685690
628
69366
F346
M
D
V
D
T
K
N
F
T
F
S
E
I
F
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623357
627
67899
S350
L
D
G
D
T
K
N
S
T
Y
A
E
K
I
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001177524
625
66606
S349
L
D
G
D
T
K
N
S
T
F
A
I
T
Y
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q7SIC9
675
72975
M403
S
N
M
T
L
L
K
M
F
G
D
F
Q
K
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23254
680
73787
Q398
W
K
E
A
L
D
F
Q
P
P
S
S
G
S
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
61.1
87.3
N.A.
94.6
94
N.A.
74.6
84.2
78.3
71
N.A.
N.A.
62.2
N.A.
61.1
Protein Similarity:
100
99.6
72.2
91.8
N.A.
97.9
97.7
N.A.
81.2
92.3
90.4
84.5
N.A.
N.A.
76.2
N.A.
76.3
P-Site Identity:
100
100
80
0
N.A.
93.3
93.3
N.A.
93.3
93.3
93.3
80
N.A.
N.A.
73.3
N.A.
73.3
P-Site Similarity:
100
100
86.6
13.3
N.A.
100
100
N.A.
100
100
100
86.6
N.A.
N.A.
86.6
N.A.
86.6
Percent
Protein Identity:
N.A.
25.3
N.A.
N.A.
25.4
N.A.
Protein Similarity:
N.A.
42.3
N.A.
N.A.
41.1
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
0
8
0
0
0
15
0
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
72
0
79
0
8
0
0
0
0
8
0
0
0
8
% D
% Glu:
0
0
8
0
0
0
0
0
0
0
0
72
0
0
0
% E
% Phe:
0
0
0
0
0
0
8
8
8
72
0
8
0
65
8
% F
% Gly:
0
0
72
0
8
0
0
0
0
8
0
0
8
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
8
29
8
0
% I
% Lys:
0
8
0
0
0
72
8
0
0
0
0
0
8
8
72
% K
% Leu:
72
0
0
0
15
8
0
0
0
0
0
0
36
0
0
% L
% Met:
8
0
8
0
0
8
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
79
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
8
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
8
% R
% Ser:
15
8
0
0
0
0
0
72
0
0
72
8
0
8
0
% S
% Thr:
0
0
0
8
79
0
0
8
79
0
0
8
8
0
0
% T
% Val:
0
8
8
8
0
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _