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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TKT
All Species:
38.48
Human Site:
S498
Identified Species:
65.13
UniProt:
P29401
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29401
NP_001055.1
623
67878
S498
Q
A
K
V
V
L
K
S
K
D
D
Q
V
T
V
Chimpanzee
Pan troglodytes
Q5R1W6
623
67821
S498
Q
A
K
V
I
L
K
S
K
D
D
Q
V
T
V
Rhesus Macaque
Macaca mulatta
XP_001095403
703
76522
S579
Q
A
K
V
V
R
H
S
V
N
D
K
V
T
V
Dog
Lupus familis
XP_533792
619
67627
D500
L
K
K
G
I
W
E
D
E
A
K
P
T
P
C
Cat
Felis silvestris
Mouse
Mus musculus
P40142
623
67612
S498
Q
A
K
V
V
L
K
S
K
D
D
Q
V
T
V
Rat
Rattus norvegicus
P50137
623
67625
S498
Q
A
K
V
V
L
K
S
K
D
D
Q
V
T
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508404
725
77819
S600
Q
A
K
V
I
L
K
S
K
D
D
Q
V
T
V
Chicken
Gallus gallus
XP_414333
627
68436
S498
Q
A
K
V
I
L
K
S
K
D
D
Q
V
T
V
Frog
Xenopus laevis
NP_001083312
627
67992
N498
H
A
K
V
V
A
Q
N
K
D
D
Q
V
T
V
Zebra Danio
Brachydanio rerio
XP_685690
628
69366
S499
Q
A
K
V
V
C
Q
S
K
E
D
Q
V
T
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623357
627
67899
S503
K
G
K
V
V
K
S
S
A
K
D
Q
V
L
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001177524
625
66606
S502
K
A
K
V
I
R
Q
S
A
E
D
K
V
V
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q7SIC9
675
72975
S558
G
Y
T
I
S
D
N
S
T
G
N
K
P
D
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23254
680
73787
V552
G
G
Y
V
L
Q
D
V
A
N
P
D
I
I
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
61.1
87.3
N.A.
94.6
94
N.A.
74.6
84.2
78.3
71
N.A.
N.A.
62.2
N.A.
61.1
Protein Similarity:
100
99.6
72.2
91.8
N.A.
97.9
97.7
N.A.
81.2
92.3
90.4
84.5
N.A.
N.A.
76.2
N.A.
76.3
P-Site Identity:
100
93.3
66.6
6.6
N.A.
100
100
N.A.
93.3
93.3
73.3
80
N.A.
N.A.
53.3
N.A.
40
P-Site Similarity:
100
100
80
26.6
N.A.
100
100
N.A.
100
100
86.6
93.3
N.A.
N.A.
60
N.A.
80
Percent
Protein Identity:
N.A.
25.3
N.A.
N.A.
25.4
N.A.
Protein Similarity:
N.A.
42.3
N.A.
N.A.
41.1
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
72
0
0
0
8
0
0
22
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
0
0
0
0
8
8
8
0
50
79
8
0
8
0
% D
% Glu:
0
0
0
0
0
0
8
0
8
15
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
15
15
0
8
0
0
0
0
0
8
0
0
0
0
0
% G
% His:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
36
0
0
0
0
0
0
0
8
8
0
% I
% Lys:
15
8
86
0
0
8
43
0
58
8
8
22
0
0
0
% K
% Leu:
8
0
0
0
8
43
0
0
0
0
0
0
0
8
22
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
8
0
15
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
8
8
8
0
% P
% Gln:
58
0
0
0
0
8
22
0
0
0
0
65
0
0
0
% Q
% Arg:
0
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
8
0
8
79
0
0
0
0
0
0
0
% S
% Thr:
0
0
8
0
0
0
0
0
8
0
0
0
8
65
0
% T
% Val:
0
0
0
86
50
0
0
8
8
0
0
0
79
8
72
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _