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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TKT
All Species:
23.64
Human Site:
T249
Identified Species:
40
UniProt:
P29401
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29401
NP_001055.1
623
67878
T249
T
F
K
G
R
G
I
T
G
V
E
D
K
E
S
Chimpanzee
Pan troglodytes
Q5R1W6
623
67821
T249
T
F
K
G
R
G
I
T
G
V
E
G
K
E
S
Rhesus Macaque
Macaca mulatta
XP_001095403
703
76522
P330
T
F
K
G
R
G
I
P
N
I
E
D
A
E
N
Dog
Lupus familis
XP_533792
619
67627
V257
Q
S
Q
K
K
I
L
V
T
P
P
Q
E
D
A
Cat
Felis silvestris
Mouse
Mus musculus
P40142
623
67612
T249
T
F
K
G
R
G
I
T
G
I
E
D
K
E
A
Rat
Rattus norvegicus
P50137
623
67625
T249
T
F
K
G
R
G
I
T
G
I
E
D
K
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508404
725
77819
A351
T
F
K
G
R
G
I
A
G
V
E
D
K
E
A
Chicken
Gallus gallus
XP_414333
627
68436
S249
T
F
K
G
K
G
I
S
G
V
E
D
K
E
S
Frog
Xenopus laevis
NP_001083312
627
67992
S249
T
F
K
G
K
G
I
S
G
V
E
D
K
E
N
Zebra Danio
Brachydanio rerio
XP_685690
628
69366
P249
T
I
K
G
K
G
I
P
V
A
E
D
K
M
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623357
627
67899
P252
T
Y
K
G
K
Y
F
P
T
I
E
D
Q
E
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001177524
625
66606
P253
T
F
K
G
K
G
C
P
D
V
E
D
L
E
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q7SIC9
675
72975
P266
T
T
I
G
F
G
S
P
N
K
A
N
S
Y
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23254
680
73787
T300
V
Y
D
H
Y
Q
K
T
I
L
K
P
G
V
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
61.1
87.3
N.A.
94.6
94
N.A.
74.6
84.2
78.3
71
N.A.
N.A.
62.2
N.A.
61.1
Protein Similarity:
100
99.6
72.2
91.8
N.A.
97.9
97.7
N.A.
81.2
92.3
90.4
84.5
N.A.
N.A.
76.2
N.A.
76.3
P-Site Identity:
100
93.3
66.6
0
N.A.
86.6
86.6
N.A.
86.6
86.6
80
53.3
N.A.
N.A.
40
N.A.
60
P-Site Similarity:
100
93.3
80
40
N.A.
100
100
N.A.
93.3
100
100
60
N.A.
N.A.
73.3
N.A.
73.3
Percent
Protein Identity:
N.A.
25.3
N.A.
N.A.
25.4
N.A.
Protein Similarity:
N.A.
42.3
N.A.
N.A.
41.1
N.A.
P-Site Identity:
N.A.
26.6
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
8
0
8
8
0
8
0
29
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
8
0
0
72
0
8
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
79
0
8
72
8
% E
% Phe:
0
65
0
0
8
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
86
0
79
0
0
50
0
0
8
8
0
8
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
8
65
0
8
29
0
0
0
0
0
% I
% Lys:
0
0
79
8
43
0
8
0
0
8
8
0
58
0
0
% K
% Leu:
0
0
0
0
0
0
8
0
0
8
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
15
0
0
8
0
0
29
% N
% Pro:
0
0
0
0
0
0
0
36
0
8
8
8
0
0
0
% P
% Gln:
8
0
8
0
0
8
0
0
0
0
0
8
8
0
0
% Q
% Arg:
0
0
0
0
43
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
8
15
0
0
0
0
8
0
29
% S
% Thr:
86
8
0
0
0
0
0
36
15
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
0
0
8
8
43
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
15
0
0
8
8
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _