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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TKT
All Species:
17.88
Human Site:
Y275
Identified Species:
30.26
UniProt:
P29401
Number Species:
13
Phosphosite Substitution
Charge Score:
0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29401
NP_001055.1
623
67878
Y275
E
Q
I
I
Q
E
I
Y
S
Q
I
Q
S
K
K
Chimpanzee
Pan troglodytes
Q5R1W6
623
67821
Y275
E
Q
I
I
Q
E
I
Y
S
Q
I
Q
S
K
K
Rhesus Macaque
Macaca mulatta
XP_001095403
703
76522
E356
D
A
I
V
K
L
I
E
S
Q
I
Q
T
N
E
Dog
Lupus familis
XP_533792
619
67627
S279
I
R
M
P
S
P
P
S
Y
K
V
G
D
K
I
Cat
Felis silvestris
Mouse
Mus musculus
P40142
623
67612
Y275
E
Q
I
I
Q
E
I
Y
S
Q
V
Q
S
K
K
Rat
Rattus norvegicus
P50137
623
67625
Y275
E
Q
I
I
Q
E
I
Y
S
Q
V
Q
S
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508404
725
77819
N377
E
Q
I
V
Q
E
I
N
T
K
I
Q
S
K
K
Chicken
Gallus gallus
XP_414333
627
68436
D275
E
Q
V
I
Q
E
I
D
E
K
I
Q
N
K
K
Frog
Xenopus laevis
NP_001083312
627
67992
E275
E
Q
S
I
K
E
I
E
G
K
I
Q
S
K
K
Zebra Danio
Brachydanio rerio
XP_685690
628
69366
S276
N
V
M
R
D
I
Q
S
R
I
M
N
S
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623357
627
67899
L280
I
Q
H
L
T
G
M
L
K
N
P
G
P
L
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001177524
625
66606
A279
G
A
L
N
A
I
K
A
L
I
S
N
P
G
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q7SIC9
675
72975
Y333
F
A
E
Y
E
K
K
Y
A
D
D
A
A
T
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23254
680
73787
A328
K
K
F
P
E
L
G
A
E
L
A
R
R
L
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
61.1
87.3
N.A.
94.6
94
N.A.
74.6
84.2
78.3
71
N.A.
N.A.
62.2
N.A.
61.1
Protein Similarity:
100
99.6
72.2
91.8
N.A.
97.9
97.7
N.A.
81.2
92.3
90.4
84.5
N.A.
N.A.
76.2
N.A.
76.3
P-Site Identity:
100
100
40
6.6
N.A.
93.3
93.3
N.A.
73.3
66.6
66.6
13.3
N.A.
N.A.
6.6
N.A.
0
P-Site Similarity:
100
100
73.3
33.3
N.A.
100
100
N.A.
93.3
86.6
80
26.6
N.A.
N.A.
20
N.A.
6.6
Percent
Protein Identity:
N.A.
25.3
N.A.
N.A.
25.4
N.A.
Protein Similarity:
N.A.
42.3
N.A.
N.A.
41.1
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
22
0
0
8
0
0
15
8
0
8
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
8
0
0
8
0
8
8
0
8
0
0
% D
% Glu:
50
0
8
0
15
50
0
15
15
0
0
0
0
0
8
% E
% Phe:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
8
8
0
8
0
0
15
0
8
8
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
15
0
43
43
0
15
58
0
0
15
43
0
0
0
8
% I
% Lys:
8
8
0
0
15
8
15
0
8
29
0
0
0
58
58
% K
% Leu:
0
0
8
8
0
15
0
8
8
8
0
0
0
15
8
% L
% Met:
0
0
15
0
0
0
8
0
0
0
8
0
0
0
0
% M
% Asn:
8
0
0
8
0
0
0
8
0
8
0
15
8
15
0
% N
% Pro:
0
0
0
15
0
8
8
0
0
0
8
0
15
0
8
% P
% Gln:
0
58
0
0
43
0
8
0
0
36
0
58
0
0
0
% Q
% Arg:
0
8
0
8
0
0
0
0
8
0
0
8
8
0
0
% R
% Ser:
0
0
8
0
8
0
0
15
36
0
8
0
50
0
8
% S
% Thr:
0
0
0
0
8
0
0
0
8
0
0
0
8
8
0
% T
% Val:
0
8
8
15
0
0
0
0
0
0
22
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
36
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _