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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOS3
All Species:
24.24
Human Site:
Y135
Identified Species:
53.33
UniProt:
P29474
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29474
NP_000594.2
1203
133289
Y135
R
D
F
I
N
Q
Y
Y
S
S
I
K
R
S
G
Chimpanzee
Pan troglodytes
XP_001148238
1153
131137
Y151
I
E
F
V
N
Q
Y
Y
G
S
F
K
E
A
K
Rhesus Macaque
Macaca mulatta
XP_001083352
1431
160593
S372
E
F
I
D
Q
Y
Y
S
S
I
K
R
F
G
S
Dog
Lupus familis
XP_534695
1431
160627
Y368
K
E
F
I
D
Q
Y
Y
S
S
I
K
R
S
G
Cat
Felis silvestris
Mouse
Mus musculus
P70313
1202
132862
Y134
R
D
F
I
N
Q
Y
Y
N
S
I
K
R
S
G
Rat
Rattus norvegicus
Q62600
1202
133271
Y134
R
D
F
I
N
Q
Y
Y
N
S
I
K
R
S
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506887
1152
131150
Y159
I
E
F
I
N
Q
Y
Y
G
S
F
K
E
A
K
Chicken
Gallus gallus
Q90703
1136
129631
Y148
V
D
F
V
K
Q
Y
Y
S
S
F
K
E
L
K
Frog
Xenopus laevis
NP_001079155
1419
160392
F356
K
E
F
I
D
Q
Y
F
S
S
I
K
R
F
G
Zebra Danio
Brachydanio rerio
NP_571735
1431
161840
T369
D
F
I
D
Q
Y
Y
T
S
I
K
R
C
C
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27571
1349
151696
F279
K
D
F
L
E
Q
Y
F
T
S
I
K
R
T
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
49.5
49.2
50.3
N.A.
93.7
93.9
N.A.
48.9
46.8
49.6
48.7
N.A.
43.8
N.A.
N.A.
N.A.
Protein Similarity:
100
64.4
62
63
N.A.
96.1
96
N.A.
63.9
63.6
63.9
62.6
N.A.
57.3
N.A.
N.A.
N.A.
P-Site Identity:
100
46.6
13.3
80
N.A.
93.3
93.3
N.A.
53.3
53.3
66.6
13.3
N.A.
53.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
66.6
20
100
N.A.
100
100
N.A.
66.6
60
93.3
20
N.A.
86.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
19
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% C
% Asp:
10
46
0
19
19
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
10
37
0
0
10
0
0
0
0
0
0
0
28
0
0
% E
% Phe:
0
19
82
0
0
0
0
19
0
0
28
0
10
10
0
% F
% Gly:
0
0
0
0
0
0
0
0
19
0
0
0
0
10
46
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
19
0
19
55
0
0
0
0
0
19
55
0
0
0
0
% I
% Lys:
28
0
0
0
10
0
0
0
0
0
19
82
0
0
28
% K
% Leu:
0
0
0
10
0
0
0
0
0
0
0
0
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
46
0
0
0
19
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
19
82
0
0
0
0
0
0
0
0
0
% Q
% Arg:
28
0
0
0
0
0
0
0
0
0
0
19
55
0
0
% R
% Ser:
0
0
0
0
0
0
0
10
55
82
0
0
0
37
28
% S
% Thr:
0
0
0
0
0
0
0
10
10
0
0
0
0
10
0
% T
% Val:
10
0
0
19
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
19
100
64
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _