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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TYK2
All Species:
30.3
Human Site:
Y433
Identified Species:
74.07
UniProt:
P29597
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29597
NP_003322.3
1187
133650
Y433
L
T
A
D
S
S
H
Y
L
C
H
E
V
A
P
Chimpanzee
Pan troglodytes
Q5IS37
825
92786
Y188
K
L
N
S
Q
N
L
Y
C
I
N
T
D
G
S
Rhesus Macaque
Macaca mulatta
XP_001101130
1120
124474
Y433
L
T
A
D
S
S
H
Y
L
C
H
E
V
A
P
Dog
Lupus familis
XP_533918
1861
202919
Y485
L
T
A
D
S
S
H
Y
L
C
H
E
V
A
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9R117
1180
132809
Y428
L
T
A
D
S
S
H
Y
L
C
H
E
V
A
P
Rat
Rattus norvegicus
Q62689
1132
130567
Y382
L
T
A
D
A
H
H
Y
L
C
K
E
V
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q75R65
1129
129828
Y380
L
T
A
D
A
H
H
Y
L
C
K
E
V
A
P
Frog
Xenopus laevis
NP_001085663
1179
135311
Y428
L
T
T
D
S
N
H
Y
L
C
H
E
V
A
P
Zebra Danio
Brachydanio rerio
O12990
1153
132463
Y418
L
T
V
D
A
H
H
Y
L
C
T
D
V
A
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24592
1177
135043
D416
L
S
S
K
W
M
Q
D
L
C
H
S
Y
R
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
21
82.1
52.7
N.A.
79.5
38.4
N.A.
N.A.
38.1
58.9
45.6
N.A.
22.9
N.A.
N.A.
N.A.
Protein Similarity:
100
36.9
85.7
57.1
N.A.
86.6
55.5
N.A.
N.A.
55.2
74.1
62.7
N.A.
38.7
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
100
100
N.A.
100
80
N.A.
N.A.
80
86.6
66.6
N.A.
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
100
100
N.A.
100
86.6
N.A.
N.A.
86.6
93.3
80
N.A.
40
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
60
0
30
0
0
0
0
0
0
0
0
80
0
% A
% Cys:
0
0
0
0
0
0
0
0
10
90
0
0
0
0
0
% C
% Asp:
0
0
0
80
0
0
0
10
0
0
0
10
10
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
70
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
30
80
0
0
0
60
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% I
% Lys:
10
0
0
10
0
0
0
0
0
0
20
0
0
0
0
% K
% Leu:
90
10
0
0
0
0
10
0
90
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
20
0
0
0
0
10
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
80
% P
% Gln:
0
0
0
0
10
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% R
% Ser:
0
10
10
10
50
40
0
0
0
0
0
10
0
0
10
% S
% Thr:
0
80
10
0
0
0
0
0
0
0
10
10
0
0
10
% T
% Val:
0
0
10
0
0
0
0
0
0
0
0
0
80
0
0
% V
% Trp:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
90
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _