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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALDH4A1 All Species: 27.27
Human Site: S191 Identified Species: 60
UniProt: P30038 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P30038 NP_003739.2 563 61719 S191 Q P I S V P P S T N S T V Y R
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_855272 938 104726 S566 Q P L S V P P S T N S V V Y R
Cat Felis silvestris
Mouse Mus musculus Q8CHT0 562 61792 S190 Q P I S V P P S T N H T V Y R
Rat Rattus norvegicus P0C2X9 563 61850 S190 Q P I S V P P S T N H V V Y R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001090548 555 61756 S184 Q P I S I P V S T N S M V Y R
Zebra Danio Brachydanio rerio Q7SY23 556 61569 S184 Q P L D S D G S T N T M L Y R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_730695 574 63648 T202 I S E N I K V T K N S L R Y R
Honey Bee Apis mellifera XP_623512 567 63503 T195 P I S P N K E T L N S M R Y R
Nematode Worm Caenorhab. elegans NP_493946 563 61733 T191 E P I S T K I T K N T M Q F R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9STS1 503 54900 K149 T F K G Y I L K E P I G V V G
Baker's Yeast Sacchar. cerevisiae P07275 575 64417 T192 P V E S A D G T W N K A E Y R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 56.4 N.A. 91.4 88 N.A. N.A. N.A. 76.5 74 N.A. 58.3 54.8 54.3 N.A.
Protein Similarity: 100 N.A. N.A. 58 N.A. 97.3 93.4 N.A. N.A. N.A. 88.4 86.3 N.A. 74 72.4 71.5 N.A.
P-Site Identity: 100 N.A. N.A. 86.6 N.A. 93.3 86.6 N.A. N.A. N.A. 80 46.6 N.A. 26.6 26.6 33.3 N.A.
P-Site Similarity: 100 N.A. N.A. 93.3 N.A. 93.3 86.6 N.A. N.A. N.A. 86.6 66.6 N.A. 46.6 33.3 60 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 25.7 42 N.A.
Protein Similarity: N.A. N.A. N.A. 41.5 60.3 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 0 0 0 0 0 10 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 0 19 0 0 0 0 0 0 0 0 0 % D
% Glu: 10 0 19 0 0 0 10 0 10 0 0 0 10 0 0 % E
% Phe: 0 10 0 0 0 0 0 0 0 0 0 0 0 10 0 % F
% Gly: 0 0 0 10 0 0 19 0 0 0 0 10 0 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 19 0 0 0 0 % H
% Ile: 10 10 46 0 19 10 10 0 0 0 10 0 0 0 0 % I
% Lys: 0 0 10 0 0 28 0 10 19 0 10 0 0 0 0 % K
% Leu: 0 0 19 0 0 0 10 0 10 0 0 10 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 37 0 0 0 % M
% Asn: 0 0 0 10 10 0 0 0 0 91 0 0 0 0 0 % N
% Pro: 19 64 0 10 0 46 37 0 0 10 0 0 0 0 0 % P
% Gln: 55 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 19 0 91 % R
% Ser: 0 10 10 64 10 0 0 55 0 0 46 0 0 0 0 % S
% Thr: 10 0 0 0 10 0 0 37 55 0 19 19 0 0 0 % T
% Val: 0 10 0 0 37 0 19 0 0 0 0 19 55 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 0 0 0 0 0 0 82 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _