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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP2R1A
All Species:
14.55
Human Site:
S558
Identified Species:
24.62
UniProt:
P30153
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30153
NP_055040.2
589
65309
S558
L
D
N
S
T
L
Q
S
E
V
K
P
I
L
E
Chimpanzee
Pan troglodytes
XP_001174531
629
69337
S598
L
D
N
S
T
L
Q
S
E
V
K
P
I
L
E
Rhesus Macaque
Macaca mulatta
XP_001116610
587
65093
S554
I
G
P
I
L
D
N
S
T
L
Q
S
E
V
K
Dog
Lupus familis
XP_541451
590
65427
S558
L
D
N
S
T
L
Q
S
E
V
K
P
I
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q7TNP2
601
65931
G570
L
D
T
N
A
L
Q
G
E
V
K
P
V
L
Q
Rat
Rattus norvegicus
Q4QQT4
601
65988
G570
L
D
T
N
A
L
Q
G
E
V
K
P
V
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519495
592
65127
G561
L
D
S
G
A
L
Q
G
E
V
K
P
V
L
H
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080135
589
65415
N558
L
D
N
S
T
L
Q
N
E
V
K
P
V
L
E
Zebra Danio
Brachydanio rerio
NP_001005590
589
65140
A558
L
E
S
S
A
L
Q
A
E
V
K
P
V
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P36179
591
65405
A560
L
E
A
S
V
I
D
A
Q
V
K
P
T
L
D
Honey Bee
Apis mellifera
XP_001120202
590
65684
A560
L
E
P
C
A
V
Q
A
Q
V
K
P
V
L
D
Nematode Worm
Caenorhab. elegans
Q09543
590
66130
S560
L
T
P
S
T
L
T
S
E
V
K
P
L
L
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q38950
587
65580
K552
V
D
Q
S
V
V
E
K
T
I
R
P
G
L
V
Baker's Yeast
Sacchar. cerevisiae
P31383
635
70933
N601
K
Y
D
A
L
I
K
N
T
I
L
P
S
L
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.6
99.1
98.8
N.A.
84.6
85
N.A.
83.1
N.A.
96
87.6
N.A.
74.4
80.1
62.2
N.A.
Protein Similarity:
100
93.6
99.1
99.1
N.A.
92
92.1
N.A.
91.5
N.A.
98.3
93.5
N.A.
84.9
89.1
76
N.A.
P-Site Identity:
100
100
6.6
100
N.A.
60
60
N.A.
60
N.A.
86.6
66.6
N.A.
40
40
73.3
N.A.
P-Site Similarity:
100
100
40
100
N.A.
80
80
N.A.
73.3
N.A.
100
93.3
N.A.
73.3
80
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
57.7
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
76.2
61.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
36
0
0
22
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
58
8
0
0
8
8
0
0
0
0
0
0
0
15
% D
% Glu:
0
22
0
0
0
0
8
0
65
0
0
0
8
0
43
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
8
0
0
0
22
0
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
8
0
0
8
0
15
0
0
0
15
0
0
22
0
0
% I
% Lys:
8
0
0
0
0
0
8
8
0
0
79
0
0
0
8
% K
% Leu:
79
0
0
0
15
65
0
0
0
8
8
0
8
93
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
29
15
0
0
8
15
0
0
0
0
0
0
0
% N
% Pro:
0
0
22
0
0
0
0
0
0
0
0
93
0
0
0
% P
% Gln:
0
0
8
0
0
0
65
0
15
0
8
0
0
0
22
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
0
0
15
58
0
0
0
36
0
0
0
8
8
0
0
% S
% Thr:
0
8
15
0
36
0
8
0
22
0
0
0
8
0
0
% T
% Val:
8
0
0
0
15
15
0
0
0
79
0
0
43
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _