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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC25A
All Species:
26.95
Human Site:
Y518
Identified Species:
65.87
UniProt:
P30304
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30304
NP_001780.2
524
59087
Y518
E
K
S
K
R
E
M
Y
S
R
L
K
K
L
_
Chimpanzee
Pan troglodytes
XP_516433
524
59098
Y518
E
K
S
K
R
E
M
Y
S
R
L
K
K
L
_
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_863396
484
54650
Y478
E
K
S
K
R
E
M
Y
S
R
L
K
K
L
_
Cat
Felis silvestris
Mouse
Mus musculus
P48964
514
57740
Y508
E
K
R
K
R
E
M
Y
S
R
L
K
K
L
_
Rat
Rattus norvegicus
P48965
525
59199
Y519
E
K
S
K
R
E
M
Y
S
R
L
K
K
L
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515667
414
45881
Chicken
Gallus gallus
XP_418479
526
59350
Y520
E
R
S
K
R
E
L
Y
S
R
L
K
K
L
_
Frog
Xenopus laevis
P30308
550
62290
V544
D
R
K
R
R
E
Q
V
A
R
L
M
K
L
_
Zebra Danio
Brachydanio rerio
NP_001108567
563
63619
Y557
E
R
S
K
R
D
M
Y
S
R
L
K
K
L
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P20483
479
54076
G468
D
G
L
G
G
A
T
G
R
L
K
K
S
R
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
84.5
N.A.
82
84.9
N.A.
57.2
63.5
36.7
46.1
N.A.
28.6
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
N.A.
88.1
N.A.
87
90.4
N.A.
64.6
76.6
51.4
60.5
N.A.
46.3
N.A.
N.A.
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
92.8
100
N.A.
0
85.7
42.8
85.7
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
92.8
100
N.A.
0
100
71.4
100
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
20
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% D
% Glu:
70
0
0
0
0
70
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
10
10
0
0
10
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
50
10
70
0
0
0
0
0
0
10
80
80
0
0
% K
% Leu:
0
0
10
0
0
0
10
0
0
10
80
0
0
80
0
% L
% Met:
0
0
0
0
0
0
60
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
30
10
10
80
0
0
0
10
80
0
0
0
10
0
% R
% Ser:
0
0
60
0
0
0
0
0
70
0
0
0
10
0
10
% S
% Thr:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
70
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
80
% _