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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC25A All Species: 26.95
Human Site: Y518 Identified Species: 65.87
UniProt: P30304 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P30304 NP_001780.2 524 59087 Y518 E K S K R E M Y S R L K K L _
Chimpanzee Pan troglodytes XP_516433 524 59098 Y518 E K S K R E M Y S R L K K L _
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_863396 484 54650 Y478 E K S K R E M Y S R L K K L _
Cat Felis silvestris
Mouse Mus musculus P48964 514 57740 Y508 E K R K R E M Y S R L K K L _
Rat Rattus norvegicus P48965 525 59199 Y519 E K S K R E M Y S R L K K L _
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515667 414 45881
Chicken Gallus gallus XP_418479 526 59350 Y520 E R S K R E L Y S R L K K L _
Frog Xenopus laevis P30308 550 62290 V544 D R K R R E Q V A R L M K L _
Zebra Danio Brachydanio rerio NP_001108567 563 63619 Y557 E R S K R D M Y S R L K K L _
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P20483 479 54076 G468 D G L G G A T G R L K K S R S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 84.5 N.A. 82 84.9 N.A. 57.2 63.5 36.7 46.1 N.A. 28.6 N.A. N.A. N.A.
Protein Similarity: 100 99.8 N.A. 88.1 N.A. 87 90.4 N.A. 64.6 76.6 51.4 60.5 N.A. 46.3 N.A. N.A. N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 92.8 100 N.A. 0 85.7 42.8 85.7 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 92.8 100 N.A. 0 100 71.4 100 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 0 0 10 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 20 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % D
% Glu: 70 0 0 0 0 70 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 10 0 10 10 0 0 10 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 50 10 70 0 0 0 0 0 0 10 80 80 0 0 % K
% Leu: 0 0 10 0 0 0 10 0 0 10 80 0 0 80 0 % L
% Met: 0 0 0 0 0 0 60 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 30 10 10 80 0 0 0 10 80 0 0 0 10 0 % R
% Ser: 0 0 60 0 0 0 0 0 70 0 0 0 10 0 10 % S
% Thr: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 70 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 80 % _