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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC25B
All Species:
10.3
Human Site:
T259
Identified Species:
25.19
UniProt:
P30305
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30305
NP_004349.1
580
64987
T259
A
L
G
R
F
S
L
T
P
A
E
G
D
T
E
Chimpanzee
Pan troglodytes
XP_514487
626
69996
T259
A
L
G
R
F
S
L
T
P
A
E
G
D
T
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_850186
574
64910
I253
A
R
C
H
F
S
L
I
A
P
R
G
P
S
E
Cat
Felis silvestris
Mouse
Mus musculus
P30306
576
65472
T257
V
A
Q
S
S
S
L
T
P
V
E
R
A
S
E
Rat
Rattus norvegicus
P48966
574
64268
T255
V
A
Q
S
S
S
L
T
P
V
E
R
A
C
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507389
566
64832
S246
L
R
R
C
S
L
T
S
I
L
V
D
E
G
D
Chicken
Gallus gallus
XP_418479
526
59350
L217
A
F
L
Q
Q
S
S
L
T
S
S
E
S
E
D
Frog
Xenopus laevis
P30310
599
67627
A266
D
P
P
C
L
D
G
A
H
D
D
I
K
M
Q
Zebra Danio
Brachydanio rerio
NP_001108567
563
63619
Q247
R
P
S
L
S
C
L
Q
D
D
D
D
D
D
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P20483
479
54076
S170
A
K
S
P
A
G
L
S
M
R
R
P
S
V
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92
N.A.
85.1
N.A.
81.2
79.8
N.A.
63.7
43.7
34.2
45.3
N.A.
25.3
N.A.
N.A.
N.A.
Protein Similarity:
100
92.1
N.A.
90.1
N.A.
88.4
85.6
N.A.
76.5
61.2
51
63.6
N.A.
41.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
N.A.
40
N.A.
40
40
N.A.
0
13.3
0
13.3
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
46.6
N.A.
46.6
40
N.A.
20
33.3
13.3
20
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
20
0
0
10
0
0
10
10
20
0
0
20
0
0
% A
% Cys:
0
0
10
20
0
10
0
0
0
0
0
0
0
10
0
% C
% Asp:
10
0
0
0
0
10
0
0
10
20
20
20
30
10
20
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
40
10
10
10
50
% E
% Phe:
0
10
0
0
30
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
20
0
0
10
10
0
0
0
0
30
0
10
10
% G
% His:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
10
10
0
0
10
0
0
0
% I
% Lys:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% K
% Leu:
10
20
10
10
10
10
70
10
0
10
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
10
0
0
0
0
10
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
20
10
10
0
0
0
0
40
10
0
10
10
0
0
% P
% Gln:
0
0
20
10
10
0
0
10
0
0
0
0
0
0
10
% Q
% Arg:
10
20
10
20
0
0
0
0
0
10
20
20
0
0
10
% R
% Ser:
0
0
20
20
40
60
10
20
0
10
10
0
20
20
0
% S
% Thr:
0
0
0
0
0
0
10
40
10
0
0
0
0
20
0
% T
% Val:
20
0
0
0
0
0
0
0
0
20
10
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _