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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC6A1 All Species: 36.97
Human Site: Y317 Identified Species: 73.94
UniProt: P30531 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P30531 NP_003033.3 599 67074 Y317 N S F H N N V Y R D S I I V C
Chimpanzee Pan troglodytes XP_516280 599 67165 Y317 N S F H N N V Y R D S I I V C
Rhesus Macaque Macaca mulatta Q9MYX0 630 70239 N354 F A S Y N K F N N N C Y Q D A
Dog Lupus familis XP_541770 599 67007 Y317 N S F H N N V Y R D S I I V C
Cat Felis silvestris
Mouse Mus musculus P31649 602 68267 Y311 N K Y H N N C Y R D C I A L C
Rat Rattus norvegicus P23978 599 66983 Y317 N S F H N N V Y R D S I I V C
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_414303 598 67057 Y316 N P F H N N V Y R D S I I V C
Frog Xenopus laevis A7Y2X0 790 87434 Y492 N K F H N N L Y R D T L I V T
Zebra Danio Brachydanio rerio NP_001007363 600 67102 Y316 N P F N N N V Y K D S I I V C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P51905 622 69307 N347 S S Y N K F N N N C Y R D A L
Honey Bee Apis mellifera NP_001128406 611 69338 Y334 N K F T N N V Y K D A L I V C
Nematode Worm Caenorhab. elegans NP_505873 610 69295 Y326 N K F N N N V Y K Q A L T V C
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 41.5 99 N.A. 51.8 98 N.A. N.A. 93.1 38.2 85 N.A. 43.7 56.9 50.3 N.A.
Protein Similarity: 100 99.1 61.7 99.5 N.A. 69.9 99.5 N.A. N.A. 96.6 53.6 92.3 N.A. 62.7 74.3 70.9 N.A.
P-Site Identity: 100 100 6.6 100 N.A. 60 100 N.A. N.A. 93.3 66.6 80 N.A. 6.6 66.6 53.3 N.A.
P-Site Similarity: 100 100 26.6 100 N.A. 73.3 100 N.A. N.A. 93.3 86.6 93.3 N.A. 26.6 86.6 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 0 0 0 0 0 0 17 0 9 9 9 % A
% Cys: 0 0 0 0 0 0 9 0 0 9 17 0 0 0 75 % C
% Asp: 0 0 0 0 0 0 0 0 0 75 0 0 9 9 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 9 0 75 0 0 9 9 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 59 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 59 67 0 0 % I
% Lys: 0 34 0 0 9 9 0 0 25 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 9 0 0 0 0 25 0 9 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 84 0 0 25 92 84 9 17 17 9 0 0 0 0 0 % N
% Pro: 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 9 0 0 9 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 59 0 0 9 0 0 0 % R
% Ser: 9 42 9 0 0 0 0 0 0 0 50 0 0 0 0 % S
% Thr: 0 0 0 9 0 0 0 0 0 0 9 0 9 0 9 % T
% Val: 0 0 0 0 0 0 67 0 0 0 0 0 0 75 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 17 9 0 0 0 84 0 0 9 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _