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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SRI All Species: 25.76
Human Site: S149 Identified Species: 51.52
UniProt: P30626 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P30626 NP_003121.1 198 21676 S149 N S I A K R Y S T N G K I T F
Chimpanzee Pan troglodytes XP_001164377 195 21319 S143 L S P Q A V N S I A K R Y S T
Rhesus Macaque Macaca mulatta XP_001104452 198 21685 S149 N S I A K R Y S T N G K I T F
Dog Lupus familis XP_532452 198 21674 S149 N S I A K R Y S T N G K I T F
Cat Felis silvestris
Mouse Mus musculus Q6P069 198 21609 S149 N S V A K R Y S T S G K I T F
Rat Rattus norvegicus Q641Z8 283 29994 S232 V S R Y C T R S A I P A M Q L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509134 180 20521 S131 N A I A K R F S T H G K I T F
Chicken Gallus gallus NP_001074334 198 21861 S149 S A I T R R Y S T H G K I T F
Frog Xenopus laevis Q5PQ53 283 30514 S232 M S R Y A Q R S A Q P G L Q L
Zebra Danio Brachydanio rerio Q6DC93 270 29406 G219 V N R Y S V R G G T G V L Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783992 192 21485 G143 N A L V R R Y G V N G R I Q F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8W4L0 335 35283 G283 S K F D K S G G R N R A I E Y
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.9 99.4 98.9 N.A. 95.9 31.4 N.A. 75.7 83.8 30.3 31.8 N.A. N.A. N.A. N.A. 60.6
Protein Similarity: 100 97.4 99.4 99.4 N.A. 98.4 42.7 N.A. 81.8 92.4 44.5 44 N.A. N.A. N.A. N.A. 72.2
P-Site Identity: 100 13.3 100 100 N.A. 86.6 13.3 N.A. 80 66.6 13.3 6.6 N.A. N.A. N.A. N.A. 46.6
P-Site Similarity: 100 26.6 100 100 N.A. 100 20 N.A. 100 93.3 26.6 20 N.A. N.A. N.A. N.A. 73.3
Percent
Protein Identity: N.A. N.A. N.A. 22.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 34.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 25 0 42 17 0 0 0 17 9 0 17 0 0 0 % A
% Cys: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % E
% Phe: 0 0 9 0 0 0 9 0 0 0 0 0 0 0 59 % F
% Gly: 0 0 0 0 0 0 9 25 9 0 67 9 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 17 0 0 0 0 0 % H
% Ile: 0 0 42 0 0 0 0 0 9 9 0 0 67 0 0 % I
% Lys: 0 9 0 0 50 0 0 0 0 0 9 50 0 0 0 % K
% Leu: 9 0 9 0 0 0 0 0 0 0 0 0 17 0 25 % L
% Met: 9 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % M
% Asn: 50 9 0 0 0 0 9 0 0 42 0 0 0 0 0 % N
% Pro: 0 0 9 0 0 0 0 0 0 0 17 0 0 0 0 % P
% Gln: 0 0 0 9 0 9 0 0 0 9 0 0 0 34 0 % Q
% Arg: 0 0 25 0 17 59 25 0 9 0 9 17 0 0 0 % R
% Ser: 17 59 0 0 9 9 0 75 0 9 0 0 0 9 0 % S
% Thr: 0 0 0 9 0 9 0 0 50 9 0 0 0 50 9 % T
% Val: 17 0 9 9 0 17 0 0 9 0 0 9 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 25 0 0 50 0 0 0 0 0 9 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _