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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SRI All Species: 32.42
Human Site: T178 Identified Species: 64.85
UniProt: P30626 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P30626 NP_003121.1 198 21676 T178 D S F R R R D T A Q Q G V V N
Chimpanzee Pan troglodytes XP_001164377 195 21319 S172 K L R A L T D S F R R R D T A
Rhesus Macaque Macaca mulatta XP_001104452 198 21685 T178 D S F R R R D T A Q Q G V V N
Dog Lupus familis XP_532452 198 21674 T178 D S F R R R D T A Q Q G V V N
Cat Felis silvestris
Mouse Mus musculus Q6P069 198 21609 S178 D S F R R R D S G Q Q G V V N
Rat Rattus norvegicus Q641Z8 283 29994 T261 E A F R E K D T A V Q G N I R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509134 180 20521 S160 D S F R R R D S T Q Q G V V N
Chicken Gallus gallus NP_001074334 198 21861 A178 E C F R R R D A S Q Q G F V N
Frog Xenopus laevis Q5PQ53 283 30514 T261 E A F R E K D T G Q I G T A K
Zebra Danio Brachydanio rerio Q6DC93 270 29406 T248 Q A F R E K D T G M T G N V R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783992 192 21485 T172 D F F R R K D T Q Q N G N A M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8W4L0 335 35283 T312 E K F K E K D T A L S G S A I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.9 99.4 98.9 N.A. 95.9 31.4 N.A. 75.7 83.8 30.3 31.8 N.A. N.A. N.A. N.A. 60.6
Protein Similarity: 100 97.4 99.4 99.4 N.A. 98.4 42.7 N.A. 81.8 92.4 44.5 44 N.A. N.A. N.A. N.A. 72.2
P-Site Identity: 100 6.6 100 100 N.A. 86.6 46.6 N.A. 86.6 66.6 40 40 N.A. N.A. N.A. N.A. 53.3
P-Site Similarity: 100 26.6 100 100 N.A. 93.3 73.3 N.A. 93.3 80 60 53.3 N.A. N.A. N.A. N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. 22.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 34.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 25 0 9 0 0 0 9 42 0 0 0 0 25 9 % A
% Cys: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 50 0 0 0 0 0 100 0 0 0 0 0 9 0 0 % D
% Glu: 34 0 0 0 34 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 9 92 0 0 0 0 0 9 0 0 0 9 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 25 0 0 92 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 9 0 0 9 9 % I
% Lys: 9 9 0 9 0 42 0 0 0 0 0 0 0 0 9 % K
% Leu: 0 9 0 0 9 0 0 0 0 9 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 9 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 9 0 25 0 50 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 9 0 0 0 0 0 0 0 9 67 59 0 0 0 0 % Q
% Arg: 0 0 9 84 59 50 0 0 0 9 9 9 0 0 17 % R
% Ser: 0 42 0 0 0 0 0 25 9 0 9 0 9 0 0 % S
% Thr: 0 0 0 0 0 9 0 67 9 0 9 0 9 9 0 % T
% Val: 0 0 0 0 0 0 0 0 0 9 0 0 42 59 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _