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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLR2B
All Species:
30.61
Human Site:
S250
Identified Species:
56.11
UniProt:
P30876
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30876
NP_000929.1
1174
133897
S250
G
G
Q
G
A
K
K
S
A
I
G
Q
R
I
V
Chimpanzee
Pan troglodytes
XP_001136218
1099
125171
F245
E
Q
N
V
A
L
N
F
I
G
S
R
G
A
K
Rhesus Macaque
Macaca mulatta
XP_001083325
1235
140431
S311
G
G
Q
G
A
K
K
S
A
I
G
Q
R
I
V
Dog
Lupus familis
XP_861018
1173
133745
S250
G
G
Q
G
A
K
K
S
A
I
G
Q
R
I
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFI7
1174
133892
S250
G
G
Q
G
A
K
K
S
A
I
G
Q
R
I
V
Rat
Rattus norvegicus
O54888
1135
127691
K254
L
P
L
G
F
A
L
K
A
L
V
S
F
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006448
1174
133860
S250
G
G
Q
G
A
K
K
S
A
I
G
Q
R
I
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001019632
1174
133813
S250
G
G
Q
G
V
K
K
S
A
I
G
Q
R
I
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08266
1176
134024
S251
G
S
Q
N
I
K
K
S
A
I
G
Q
R
I
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10578
1193
134886
T256
G
G
G
G
G
K
K
T
A
M
G
Q
R
I
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P38420
1188
135001
S256
R
A
S
A
K
G
G
S
S
G
Q
Y
I
R
C
Baker's Yeast
Sacchar. cerevisiae
P08518
1224
138733
G263
V
K
L
Y
G
R
E
G
S
S
A
R
T
I
K
Red Bread Mold
Neurospora crassa
O74633
1234
138583
F256
D
G
N
V
T
F
R
F
S
W
R
K
N
E
Y
Conservation
Percent
Protein Identity:
100
93.4
95
99.6
N.A.
99.9
26.9
N.A.
N.A.
99.4
N.A.
97
N.A.
85.9
N.A.
77.8
N.A.
Protein Similarity:
100
93.6
95
99.7
N.A.
100
43.4
N.A.
N.A.
99.8
N.A.
99.3
N.A.
94
N.A.
88.8
N.A.
P-Site Identity:
100
6.6
100
100
N.A.
100
13.3
N.A.
N.A.
100
N.A.
93.3
N.A.
73.3
N.A.
66.6
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
20
N.A.
N.A.
100
N.A.
93.3
N.A.
80
N.A.
86.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
66.6
58.7
26.4
Protein Similarity:
N.A.
N.A.
N.A.
80.1
74.2
44.3
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
47
8
0
0
70
0
8
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% D
% Glu:
8
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% E
% Phe:
0
0
0
0
8
8
0
16
0
0
0
0
8
0
0
% F
% Gly:
62
62
8
62
16
8
8
8
0
16
62
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
8
54
0
0
8
70
16
% I
% Lys:
0
8
0
0
8
62
62
8
0
0
0
8
0
0
16
% K
% Leu:
8
0
16
0
0
8
8
0
0
8
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
16
8
0
0
8
0
0
0
0
0
8
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
54
0
0
0
0
0
0
0
8
62
0
0
0
% Q
% Arg:
8
0
0
0
0
8
8
0
0
0
8
16
62
8
0
% R
% Ser:
0
8
8
0
0
0
0
62
24
8
8
8
0
8
0
% S
% Thr:
0
0
0
0
8
0
0
8
0
0
0
0
8
0
0
% T
% Val:
8
0
0
16
8
0
0
0
0
0
8
0
0
0
47
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _