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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLR2B
All Species:
30.61
Human Site:
Y689
Identified Species:
56.11
UniProt:
P30876
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30876
NP_000929.1
1174
133897
Y689
L
Q
E
K
E
V
A
Y
C
S
T
Y
T
H
C
Chimpanzee
Pan troglodytes
XP_001136218
1099
125171
M627
H
C
E
I
H
P
S
M
I
L
G
V
C
A
S
Rhesus Macaque
Macaca mulatta
XP_001083325
1235
140431
Y750
L
Q
E
K
E
V
A
Y
C
S
T
Y
T
H
C
Dog
Lupus familis
XP_861018
1173
133745
Y688
L
Q
E
K
E
V
A
Y
C
S
T
Y
T
H
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFI7
1174
133892
Y689
L
Q
E
K
E
V
A
Y
C
S
T
Y
T
H
C
Rat
Rattus norvegicus
O54888
1135
127691
F652
C
H
L
R
G
R
G
F
W
W
S
F
H
T
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006448
1174
133860
Y689
L
Q
E
K
G
V
A
Y
C
S
T
Y
T
H
C
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001019632
1174
133813
Y689
L
Q
E
K
G
V
A
Y
C
S
T
Y
T
H
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08266
1176
134024
Y691
K
Q
D
K
D
Y
A
Y
C
T
T
Y
T
H
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10578
1193
134886
Y695
E
D
L
R
S
G
G
Y
C
D
T
H
T
H
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P38420
1188
135001
Y697
R
L
R
P
E
E
A
Y
T
E
N
Y
T
H
C
Baker's Yeast
Sacchar. cerevisiae
P08518
1224
138733
H734
K
R
I
R
V
S
H
H
A
T
T
F
T
H
C
Red Bread Mold
Neurospora crassa
O74633
1234
138583
I685
A
C
T
E
Q
E
V
I
P
G
D
S
T
H
V
Conservation
Percent
Protein Identity:
100
93.4
95
99.6
N.A.
99.9
26.9
N.A.
N.A.
99.4
N.A.
97
N.A.
85.9
N.A.
77.8
N.A.
Protein Similarity:
100
93.6
95
99.7
N.A.
100
43.4
N.A.
N.A.
99.8
N.A.
99.3
N.A.
94
N.A.
88.8
N.A.
P-Site Identity:
100
6.6
100
100
N.A.
100
0
N.A.
N.A.
93.3
N.A.
93.3
N.A.
66.6
N.A.
40
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
26.6
N.A.
N.A.
93.3
N.A.
93.3
N.A.
86.6
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
66.6
58.7
26.4
Protein Similarity:
N.A.
N.A.
N.A.
80.1
74.2
44.3
P-Site Identity:
N.A.
N.A.
N.A.
46.6
26.6
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
60
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
62
0
8
0
0
0
0
8
0
% A
% Cys:
8
16
0
0
0
0
0
0
62
0
0
0
8
0
77
% C
% Asp:
0
8
8
0
8
0
0
0
0
8
8
0
0
0
0
% D
% Glu:
8
0
54
8
39
16
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
16
0
0
0
% F
% Gly:
0
0
0
0
24
8
16
0
0
8
8
0
0
0
0
% G
% His:
8
8
0
0
8
0
8
8
0
0
0
8
8
85
0
% H
% Ile:
0
0
8
8
0
0
0
8
8
0
0
0
0
0
0
% I
% Lys:
16
0
0
54
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
47
8
16
0
0
0
0
0
0
8
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
8
0
8
0
0
8
0
0
0
0
0
8
% P
% Gln:
0
54
0
0
8
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
8
8
24
0
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
8
8
8
0
0
47
8
8
0
0
8
% S
% Thr:
0
0
8
0
0
0
0
0
8
16
70
0
85
8
0
% T
% Val:
0
0
0
0
8
47
8
0
0
0
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
70
0
0
0
62
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _