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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPK4
All Species:
12.42
Human Site:
S521
Identified Species:
30.37
UniProt:
P31152
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31152
NP_002738.2
587
65922
S521
P
E
R
R
L
S
A
S
P
P
G
R
P
A
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001094390
587
65900
S521
P
E
H
R
L
S
A
S
P
P
G
R
P
A
P
Dog
Lupus familis
XP_548811
584
65457
S519
P
E
R
R
P
A
A
S
P
P
S
R
A
A
P
Cat
Felis silvestris
Mouse
Mus musculus
Q6P5G0
583
65556
S517
P
E
P
R
L
S
A
S
P
P
G
H
P
T
P
Rat
Rattus norvegicus
P27704
720
82256
A537
A
G
T
V
Q
L
S
A
Q
R
E
S
A
D
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508507
579
65970
A517
S
S
P
H
H
H
R
A
P
K
E
A
N
H
S
Chicken
Gallus gallus
Q5F3W3
721
82729
L537
F
I
A
E
T
I
Q
L
S
L
Q
H
E
P
T
Frog
Xenopus laevis
P26696
361
41238
A309
H
K
R
I
E
V
E
A
A
L
A
H
P
Y
L
Zebra Danio
Brachydanio rerio
NP_998638
674
75893
L535
P
C
S
P
P
L
P
L
S
P
T
L
M
P
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_792156
763
86571
T616
E
N
K
E
L
D
L
T
D
T
L
D
I
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.9
92.8
N.A.
93.5
48
N.A.
83.9
48.6
28.2
53.8
N.A.
N.A.
N.A.
N.A.
32.6
Protein Similarity:
100
N.A.
99.3
94.7
N.A.
95.5
60.9
N.A.
90.1
61.8
42.4
65.7
N.A.
N.A.
N.A.
N.A.
48.8
P-Site Identity:
100
N.A.
93.3
73.3
N.A.
80
0
N.A.
6.6
0
13.3
13.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
N.A.
93.3
80
N.A.
80
13.3
N.A.
13.3
0
26.6
13.3
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
0
10
40
30
10
0
10
10
20
30
0
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
10
0
0
10
0
0
10
0
10
0
% D
% Glu:
10
40
0
20
10
0
10
0
0
0
20
0
10
0
0
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
0
0
0
0
0
30
0
0
0
0
% G
% His:
10
0
10
10
10
10
0
0
0
0
0
30
0
10
0
% H
% Ile:
0
10
0
10
0
10
0
0
0
0
0
0
10
0
0
% I
% Lys:
0
10
10
0
0
0
0
0
0
10
0
0
0
0
10
% K
% Leu:
0
0
0
0
40
20
10
20
0
20
10
10
0
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
50
0
20
10
20
0
10
0
50
50
0
0
40
20
40
% P
% Gln:
0
0
0
0
10
0
10
0
10
0
10
0
0
0
10
% Q
% Arg:
0
0
30
40
0
0
10
0
0
10
0
30
0
0
0
% R
% Ser:
10
10
10
0
0
30
10
40
20
0
10
10
0
0
10
% S
% Thr:
0
0
10
0
10
0
0
10
0
10
10
0
0
10
10
% T
% Val:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _