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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPK4
All Species:
30
Human Site:
Y451
Identified Species:
73.33
UniProt:
P31152
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31152
NP_002738.2
587
65922
Y451
R
D
N
K
P
H
H
Y
S
E
P
K
L
I
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001094390
587
65900
Y451
R
D
N
K
P
H
H
Y
S
E
P
K
L
I
L
Dog
Lupus familis
XP_548811
584
65457
Y449
R
D
S
K
P
H
H
Y
S
E
P
K
L
I
L
Cat
Felis silvestris
Mouse
Mus musculus
Q6P5G0
583
65556
Y447
R
D
N
K
P
H
H
Y
S
E
P
K
L
I
L
Rat
Rattus norvegicus
P27704
720
82256
Y467
R
E
S
E
V
N
H
Y
Y
E
P
K
L
I
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508507
579
65970
Y447
R
D
N
K
P
H
H
Y
S
E
P
K
L
I
L
Chicken
Gallus gallus
Q5F3W3
721
82729
Y467
R
D
S
E
V
N
H
Y
Y
E
P
K
L
I
I
Frog
Xenopus laevis
P26696
361
41238
Q239
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
Zebra Danio
Brachydanio rerio
NP_998638
674
75893
Y465
R
E
G
K
P
Q
H
Y
S
E
P
K
L
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_792156
763
86571
N546
E
D
N
T
G
D
N
N
K
K
E
E
E
K
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.9
92.8
N.A.
93.5
48
N.A.
83.9
48.6
28.2
53.8
N.A.
N.A.
N.A.
N.A.
32.6
Protein Similarity:
100
N.A.
99.3
94.7
N.A.
95.5
60.9
N.A.
90.1
61.8
42.4
65.7
N.A.
N.A.
N.A.
N.A.
48.8
P-Site Identity:
100
N.A.
100
93.3
N.A.
100
53.3
N.A.
100
60
6.6
80
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
N.A.
100
100
N.A.
100
86.6
N.A.
100
86.6
13.3
86.6
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
70
0
0
0
10
10
0
0
0
0
0
0
0
0
% D
% Glu:
10
20
0
20
0
0
0
0
0
80
10
10
10
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
10
0
10
0
0
0
0
0
0
0
0
10
0
% G
% His:
0
0
0
10
0
50
80
0
0
0
10
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
10
0
80
30
% I
% Lys:
0
0
10
60
0
0
0
0
10
10
0
80
0
10
0
% K
% Leu:
0
0
0
0
0
10
0
0
10
0
0
0
90
0
60
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
50
0
0
20
10
10
0
10
0
0
0
0
0
% N
% Pro:
10
0
0
0
60
0
0
0
0
0
80
0
0
0
0
% P
% Gln:
0
0
0
0
0
10
0
10
0
0
0
0
0
0
0
% Q
% Arg:
80
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
30
0
0
0
0
0
60
0
0
0
0
0
0
% S
% Thr:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
10
% T
% Val:
0
0
0
0
20
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
80
20
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _