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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAT2A All Species: 57.88
Human Site: S95 Identified Species: 79.58
UniProt: P31153 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P31153 NP_005902.1 395 43661 S95 K H I G Y D D S S K G F D Y K
Chimpanzee Pan troglodytes XP_515585 413 45605 S95 K H I G Y D D S S K G F D Y K
Rhesus Macaque Macaca mulatta XP_001083990 438 48324 S138 K H I G Y D D S S K G F D Y K
Dog Lupus familis XP_532980 395 43656 S95 K H I G Y D D S S K G F D Y K
Cat Felis silvestris
Mouse Mus musculus Q3THS6 395 43670 S95 K H I G Y D D S S K G F D Y K
Rat Rattus norvegicus P18298 395 43697 S95 K H I G Y D D S S K G F D Y K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508946 392 42919 V92 Q Q D P D A K V A C G F D Y K
Chicken Gallus gallus XP_421512 396 43734 S96 R H I G Y D D S A K G F D Y K
Frog Xenopus laevis NP_001080175 396 43767 S96 K Y I G Y D D S S K G F D Y K
Zebra Danio Brachydanio rerio NP_001014318 363 40041 S96 K H I G Y D D S T K G F D Y K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P40320 408 44678 S106 Q H I G Y D D S S K G F D F K
Honey Bee Apis mellifera XP_623669 404 44652 S103 K H I G Y D D S S K G F D W H
Nematode Worm Caenorhab. elegans P50305 404 44016 S83 K K I G Y D D S S K G F D Y K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa A9PDZ7 393 42904 D81 R S I G F V S D D V G L D A D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LUT2 393 42777 A81 R E I G F V S A D V G L D A D
Baker's Yeast Sacchar. cerevisiae P10659 382 41800 S82 K K I G Y D D S A K G F D Y K
Red Bread Mold Neurospora crassa P48466 395 42967 S94 K D I G Y D D S S K G F D Y K
Conservation
Percent
Protein Identity: 100 93.9 84.9 99.7 N.A. 99.4 98.4 N.A. 77.9 84 91.1 82.2 N.A. 71.3 71.7 70.5 N.A.
Protein Similarity: 100 94.1 86.3 100 N.A. 100 99.7 N.A. 82 92.4 97.4 88.3 N.A. 85.5 85.4 81.4 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 33.3 86.6 93.3 93.3 N.A. 86.6 86.6 93.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 46.6 100 100 100 N.A. 100 93.3 93.3 N.A.
Percent
Protein Identity: 64.8 N.A. N.A. 64.3 66 68.8
Protein Similarity: 76.2 N.A. N.A. 78.2 81.5 83
P-Site Identity: 26.6 N.A. N.A. 26.6 86.6 93.3
P-Site Similarity: 40 N.A. N.A. 46.6 93.3 93.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 6 0 6 18 0 0 0 0 12 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % C
% Asp: 0 6 6 0 6 83 83 6 12 0 0 0 100 0 12 % D
% Glu: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 12 0 0 0 0 0 0 89 0 6 0 % F
% Gly: 0 0 0 95 0 0 0 0 0 0 100 0 0 0 0 % G
% His: 0 59 0 0 0 0 0 0 0 0 0 0 0 0 6 % H
% Ile: 0 0 95 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 71 12 0 0 0 0 6 0 0 83 0 0 0 0 83 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 12 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 18 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 6 0 0 0 0 12 83 65 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 12 0 6 0 12 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % W
% Tyr: 0 6 0 0 83 0 0 0 0 0 0 0 0 77 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _