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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAT2A All Species: 47.58
Human Site: T172 Identified Species: 65.42
UniProt: P31153 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P31153 NP_005902.1 395 43661 T172 A E L R R N G T L P W L R P D
Chimpanzee Pan troglodytes XP_515585 413 45605 T172 A E L R R N G T L P W L R P D
Rhesus Macaque Macaca mulatta XP_001083990 438 48324 T215 A E L R R N G T L P W L R P D
Dog Lupus familis XP_532980 395 43656 T172 A E L R R N G T L P W L R P D
Cat Felis silvestris
Mouse Mus musculus Q3THS6 395 43670 T172 A E L R R N G T L P W L R P D
Rat Rattus norvegicus P18298 395 43697 T172 A E L R R N G T L P W L R P D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508946 392 42919 T169 A E L R R N G T L P W L R P D
Chicken Gallus gallus XP_421512 396 43734 E173 A E L R R S G E L P W L R P D
Frog Xenopus laevis NP_001080175 396 43767 T173 A E L R R N G T L P W L R P D
Zebra Danio Brachydanio rerio NP_001014318 363 40041 R170 S K M A E L R R N G T L P W L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P40320 408 44678 V183 A E L R R S D V F W W A R P D
Honey Bee Apis mellifera XP_623669 404 44652 E180 A E L R R S G E L W W A R P D
Nematode Worm Caenorhab. elegans P50305 404 44016 E160 H E L R R S G E L E W V R P D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa A9PDZ7 393 42904 T160 T E V R K N G T C P W L R P D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LUT2 393 42777 T160 T E V R K N G T C P W L R P D
Baker's Yeast Sacchar. cerevisiae P10659 382 41800 S159 A D A R R D G S L A W L R P D
Red Bread Mold Neurospora crassa P48466 395 42967 S171 S A A R R D G S L P W L R P D
Conservation
Percent
Protein Identity: 100 93.9 84.9 99.7 N.A. 99.4 98.4 N.A. 77.9 84 91.1 82.2 N.A. 71.3 71.7 70.5 N.A.
Protein Similarity: 100 94.1 86.3 100 N.A. 100 99.7 N.A. 82 92.4 97.4 88.3 N.A. 85.5 85.4 81.4 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 86.6 100 6.6 N.A. 60 73.3 66.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 93.3 100 26.6 N.A. 66.6 80 80 N.A.
Percent
Protein Identity: 64.8 N.A. N.A. 64.3 66 68.8
Protein Similarity: 76.2 N.A. N.A. 78.2 81.5 83
P-Site Identity: 73.3 N.A. N.A. 73.3 66.6 66.6
P-Site Similarity: 86.6 N.A. N.A. 86.6 86.6 86.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 71 6 12 6 0 0 0 0 0 6 0 12 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % C
% Asp: 0 6 0 0 0 12 6 0 0 0 0 0 0 0 95 % D
% Glu: 0 83 0 0 6 0 0 18 0 6 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 89 0 0 6 0 0 0 0 0 % G
% His: 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 6 0 0 12 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 71 0 0 6 0 0 77 0 0 83 0 0 6 % L
% Met: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 59 0 0 6 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 71 0 0 6 95 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 95 83 0 6 6 0 0 0 0 95 0 0 % R
% Ser: 12 0 0 0 0 24 0 12 0 0 0 0 0 0 0 % S
% Thr: 12 0 0 0 0 0 0 59 0 0 6 0 0 0 0 % T
% Val: 0 0 12 0 0 0 0 6 0 0 0 6 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 12 95 0 0 6 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _