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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RRM2
All Species:
19.39
Human Site:
T33
Identified Species:
30.48
UniProt:
P31350
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31350
NP_001025.1
389
44878
T33
S
L
V
D
K
E
N
T
P
P
A
L
S
G
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100144
351
40744
S29
T
N
D
N
E
I
K
S
N
E
E
P
L
L
R
Dog
Lupus familis
XP_540076
394
45449
T38
S
L
A
D
K
E
N
T
P
P
A
L
S
G
T
Cat
Felis silvestris
Mouse
Mus musculus
P11157
390
45077
T33
T
L
A
D
K
E
N
T
P
P
T
L
S
S
T
Rat
Rattus norvegicus
Q4KLN6
390
45020
T33
S
L
A
D
K
E
N
T
P
P
T
L
S
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506085
394
45462
T37
H
L
A
D
K
E
N
T
P
P
S
L
N
I
T
Chicken
Gallus gallus
XP_419948
384
44421
P33
S
D
K
E
N
T
P
P
A
L
S
S
S
R
V
Frog
Xenopus laevis
NP_001080772
386
44577
T36
T
P
P
T
L
N
S
T
R
V
L
A
S
K
T
Zebra Danio
Brachydanio rerio
P79733
386
44575
S34
D
K
E
N
T
P
P
S
L
S
S
T
R
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48592
393
45096
G42
S
I
G
H
E
A
N
G
Q
L
A
K
E
S
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P42170
381
44271
K34
K
L
E
K
E
L
E
K
L
E
I
V
D
Q
T
Sea Urchin
Strong. purpuratus
XP_780110
412
47263
E47
K
P
R
A
I
L
G
E
V
Q
N
L
P
Q
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q6Y657
333
38312
T11
M
P
E
E
P
I
L
T
P
T
P
D
R
F
C
Baker's Yeast
Sacchar. cerevisiae
P09938
399
46129
E46
V
K
S
D
M
L
K
E
K
L
S
K
D
A
E
Red Bread Mold
Neurospora crassa
Q9C167
410
46679
K37
G
A
T
D
K
E
N
K
P
F
D
E
D
L
A
Conservation
Percent
Protein Identity:
100
N.A.
72.4
95.4
N.A.
91.2
89.7
N.A.
90.6
88.4
84
83.5
N.A.
68.9
N.A.
59.9
67.9
Protein Similarity:
100
N.A.
82
96.4
N.A.
95.3
94.6
N.A.
95.4
94
91
90.7
N.A.
79.3
N.A.
74.8
77.6
P-Site Identity:
100
N.A.
0
93.3
N.A.
73.3
73.3
N.A.
66.6
13.3
20
0
N.A.
20
N.A.
13.3
6.6
P-Site Similarity:
100
N.A.
26.6
93.3
N.A.
80
73.3
N.A.
80
26.6
33.3
20
N.A.
40
N.A.
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
58.8
58.4
64.3
Protein Similarity:
N.A.
N.A.
N.A.
69.9
71.4
75.8
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
33.3
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
27
7
0
7
0
0
7
0
20
7
0
7
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
7
7
7
47
0
0
0
0
0
0
7
7
20
0
0
% D
% Glu:
0
0
20
14
20
40
7
14
0
14
7
7
7
0
14
% E
% Phe:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% F
% Gly:
7
0
7
0
0
0
7
7
0
0
0
0
0
14
0
% G
% His:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
7
14
0
0
0
0
7
0
0
14
0
% I
% Lys:
14
14
7
7
40
0
14
14
7
0
0
14
0
7
0
% K
% Leu:
0
40
0
0
7
20
7
0
14
20
7
40
7
14
7
% L
% Met:
7
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
14
7
7
47
0
7
0
7
0
7
0
0
% N
% Pro:
0
20
7
0
7
7
14
7
47
34
7
7
7
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
7
7
0
0
0
14
0
% Q
% Arg:
0
0
7
0
0
0
0
0
7
0
0
0
14
7
7
% R
% Ser:
34
0
7
0
0
0
7
14
0
7
27
7
40
20
7
% S
% Thr:
20
0
7
7
7
7
0
47
0
7
14
7
0
0
40
% T
% Val:
7
0
7
0
0
0
0
0
7
7
0
7
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _