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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC6A4
All Species:
20
Human Site:
S8
Identified Species:
40
UniProt:
P31645
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31645
NP_001036.1
630
70325
S8
M
E
T
T
P
L
N
S
Q
K
Q
L
S
A
C
Chimpanzee
Pan troglodytes
XP_001135066
630
70262
S8
M
E
T
T
P
L
N
S
Q
K
Q
L
S
A
C
Rhesus Macaque
Macaca mulatta
Q9MYX0
630
70239
S8
M
E
T
T
P
L
N
S
Q
K
Q
L
S
A
C
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q60857
630
70129
S8
M
E
T
T
P
L
N
S
Q
K
V
L
S
E
C
Rat
Rattus norvegicus
P31652
630
70153
S8
M
E
T
T
P
L
N
S
Q
K
V
L
S
E
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508462
865
94609
A61
Y
I
T
R
S
P
P
A
R
R
G
Q
S
S
R
Chicken
Gallus gallus
NP_998737
670
74409
S15
N
E
T
Q
P
L
T
S
K
K
G
I
S
D
C
Frog
Xenopus laevis
A7Y2W8
633
71004
A13
N
G
A
V
P
S
E
A
T
K
K
D
E
N
L
Zebra Danio
Brachydanio rerio
NP_001035061
646
72103
N10
M
K
E
S
M
M
M
N
Q
E
Y
G
G
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P51905
622
69307
D8
M
D
R
S
G
S
S
D
F
A
G
A
A
A
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03614
615
69247
P9
Q
L
V
P
T
D
D
P
D
E
K
I
G
R
T
Sea Urchin
Strong. purpuratus
XP_001204030
641
70931
N16
I
E
P
Q
S
P
D
N
I
V
Q
L
D
Q
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
N.A.
N.A.
92.8
91.7
N.A.
38.1
77.6
42.1
68.5
N.A.
50.4
N.A.
43.6
49.4
Protein Similarity:
100
99.5
99.5
N.A.
N.A.
95.5
94.9
N.A.
52.9
85.2
60.8
80.6
N.A.
66.9
N.A.
63.3
66.6
P-Site Identity:
100
100
100
N.A.
N.A.
86.6
86.6
N.A.
13.3
53.3
13.3
13.3
N.A.
13.3
N.A.
0
20
P-Site Similarity:
100
100
100
N.A.
N.A.
86.6
86.6
N.A.
40
66.6
26.6
46.6
N.A.
40
N.A.
26.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
0
17
0
9
0
9
9
34
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
50
% C
% Asp:
0
9
0
0
0
9
17
9
9
0
0
9
9
9
0
% D
% Glu:
0
59
9
0
0
0
9
0
0
17
0
0
9
25
0
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
9
0
0
0
0
0
25
9
17
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
9
0
0
0
0
0
0
9
0
0
17
0
0
0
% I
% Lys:
0
9
0
0
0
0
0
0
9
59
17
0
0
0
0
% K
% Leu:
0
9
0
0
0
50
0
0
0
0
0
50
0
0
9
% L
% Met:
59
0
0
0
9
9
9
0
0
0
0
0
0
0
0
% M
% Asn:
17
0
0
0
0
0
42
17
0
0
0
0
0
9
0
% N
% Pro:
0
0
9
9
59
17
9
9
0
0
0
0
0
0
0
% P
% Gln:
9
0
0
17
0
0
0
0
50
0
34
9
0
9
9
% Q
% Arg:
0
0
9
9
0
0
0
0
9
9
0
0
0
9
9
% R
% Ser:
0
0
0
17
17
17
9
50
0
0
0
0
59
9
9
% S
% Thr:
0
0
59
42
9
0
9
0
9
0
0
0
0
0
17
% T
% Val:
0
0
9
9
0
0
0
0
0
9
17
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _