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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC6A4
All Species:
22.73
Human Site:
Y142
Identified Species:
45.45
UniProt:
P31645
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31645
NP_001036.1
630
70325
Y142
M
E
L
A
L
G
Q
Y
H
R
N
G
C
I
S
Chimpanzee
Pan troglodytes
XP_001135066
630
70262
Y142
M
E
L
A
L
G
Q
Y
H
R
N
G
C
I
S
Rhesus Macaque
Macaca mulatta
Q9MYX0
630
70239
Y142
M
E
L
A
L
G
Q
Y
H
R
N
G
C
I
S
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q60857
630
70129
Y142
M
E
L
A
L
G
Q
Y
H
R
N
G
C
I
S
Rat
Rattus norvegicus
P31652
630
70153
Y142
M
E
L
A
L
G
Q
Y
H
R
N
G
C
I
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508462
865
94609
A372
G
Q
Y
N
R
E
G
A
A
T
V
W
K
I
C
Chicken
Gallus gallus
NP_998737
670
74409
Y182
M
E
L
A
L
G
Q
Y
H
R
N
G
C
I
S
Frog
Xenopus laevis
A7Y2W8
633
71004
A152
L
W
N
T
N
N
C
A
G
V
L
S
P
N
S
Zebra Danio
Brachydanio rerio
NP_001035061
646
72103
H155
E
L
A
L
G
Q
F
H
R
S
G
C
I
S
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P51905
622
69307
F137
M
E
L
A
L
G
Q
F
H
R
C
G
C
L
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03614
615
69247
I140
V
D
F
F
Y
N
V
I
L
A
W
G
L
H
Y
Sea Urchin
Strong. purpuratus
XP_001204030
641
70931
L151
F
L
Y
M
E
M
A
L
G
Q
Y
Q
R
T
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
N.A.
N.A.
92.8
91.7
N.A.
38.1
77.6
42.1
68.5
N.A.
50.4
N.A.
43.6
49.4
Protein Similarity:
100
99.5
99.5
N.A.
N.A.
95.5
94.9
N.A.
52.9
85.2
60.8
80.6
N.A.
66.9
N.A.
63.3
66.6
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
6.6
100
6.6
0
N.A.
80
N.A.
6.6
0
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
13.3
100
13.3
6.6
N.A.
93.3
N.A.
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
59
0
0
9
17
9
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
9
0
0
0
9
9
59
0
9
% C
% Asp:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
9
59
0
0
9
9
0
0
0
0
0
0
0
0
0
% E
% Phe:
9
0
9
9
0
0
9
9
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
0
9
59
9
0
17
0
9
67
0
0
9
% G
% His:
0
0
0
0
0
0
0
9
59
0
0
0
0
9
0
% H
% Ile:
0
0
0
0
0
0
0
9
0
0
0
0
9
59
9
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% K
% Leu:
9
17
59
9
59
0
0
9
9
0
9
0
9
9
0
% L
% Met:
59
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
9
9
17
0
0
0
0
50
0
0
9
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% P
% Gln:
0
9
0
0
0
9
59
0
0
9
0
9
0
0
0
% Q
% Arg:
0
0
0
0
9
0
0
0
9
59
0
0
9
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
9
0
9
0
9
67
% S
% Thr:
0
0
0
9
0
0
0
0
0
9
0
0
0
9
0
% T
% Val:
9
0
0
0
0
0
9
0
0
9
9
0
0
0
0
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
9
9
0
0
0
% W
% Tyr:
0
0
17
0
9
0
0
50
0
0
9
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _