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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AKT2
All Species:
26.67
Human Site:
T449
Identified Species:
53.33
UniProt:
P31751
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31751
NP_001617.1
481
55769
T449
E
F
T
A
Q
S
I
T
I
T
P
P
D
R
Y
Chimpanzee
Pan troglodytes
XP_512662
481
55720
T449
E
F
T
A
Q
S
I
T
I
T
P
P
D
R
Y
Rhesus Macaque
Macaca mulatta
XP_001093137
481
55690
T449
E
F
T
A
Q
S
I
T
I
T
P
P
D
R
Y
Dog
Lupus familis
XP_548000
481
55446
T449
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
G
Cat
Felis silvestris
Mouse
Mus musculus
Q60823
481
55723
T449
E
F
T
A
Q
S
I
T
I
T
P
P
D
R
Y
Rat
Rattus norvegicus
P47197
481
55525
T449
E
F
T
A
Q
S
I
T
I
T
P
P
D
R
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513899
512
59226
E479
T
D
T
R
Y
F
D
E
E
F
T
A
Q
T
I
Chicken
Gallus gallus
Q6U1I9
432
48872
Q401
P
V
P
N
S
I
G
Q
S
P
D
S
I
L
I
Frog
Xenopus laevis
Q7ZX15
486
56292
T454
E
F
T
A
Q
S
I
T
L
T
P
P
D
R
Y
Zebra Danio
Brachydanio rerio
Q7ZTW4
433
48964
C402
P
V
P
N
S
I
G
C
S
P
D
S
A
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8INB9
611
68466
E563
E
F
T
G
E
S
V
E
L
T
P
P
D
P
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17941
541
62181
Q490
E
F
T
S
Q
P
V
Q
L
T
P
P
S
R
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
79.4
N.A.
98.1
97.7
N.A.
69.3
39.7
87.6
39.9
N.A.
49.2
N.A.
52.6
N.A.
Protein Similarity:
100
99.7
99.5
89.4
N.A.
98.7
98.5
N.A.
80
55.2
93.4
57.1
N.A.
61.8
N.A.
69.6
N.A.
P-Site Identity:
100
100
100
80
N.A.
100
100
N.A.
6.6
0
93.3
0
N.A.
53.3
N.A.
53.3
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
100
100
N.A.
6.6
0
100
0
N.A.
73.3
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
59
0
0
0
0
0
0
0
9
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
0
9
0
0
0
17
0
67
0
0
% D
% Glu:
75
0
0
0
9
0
0
17
9
0
0
0
0
0
0
% E
% Phe:
0
75
0
0
0
9
0
0
0
9
0
0
0
0
0
% F
% Gly:
0
0
0
9
0
0
17
0
0
0
0
0
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
17
59
0
50
0
0
0
9
0
17
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
25
0
0
0
0
17
0
% L
% Met:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
17
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
17
0
17
0
0
9
0
0
0
17
75
75
0
9
0
% P
% Gln:
0
0
0
0
67
0
0
17
0
0
0
0
9
9
0
% Q
% Arg:
0
0
0
9
0
0
0
0
0
0
0
0
0
59
0
% R
% Ser:
0
0
0
9
17
59
0
0
17
0
0
17
9
0
9
% S
% Thr:
9
0
84
0
0
0
0
59
0
75
9
0
0
9
9
% T
% Val:
0
17
0
0
0
0
17
0
0
0
0
0
0
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
50
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _