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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SFN All Species: 23.03
Human Site: Y48 Identified Species: 42.22
UniProt: P31947 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P31947 NP_006133.1 248 27774 Y48 R N L L S V A Y K N V V G G Q
Chimpanzee Pan troglodytes XP_528202 382 42115 V183 E E R N L L S V A Y K N V V G
Rhesus Macaque Macaca mulatta XP_001110323 248 27784 Y48 R N L L S V A Y K N V V G G Q
Dog Lupus familis XP_544477 248 27815 Y48 R N L L S V A Y K N V V G G Q
Cat Felis silvestris
Mouse Mus musculus O70456 248 27695 Y48 R N L L S V A Y K N V V G G Q
Rat Rattus norvegicus P63102 245 27753 V46 E E R N L L S V A Y K N V V G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511520 248 27538 Y48 R N L L S V A Y K N V V G G Q
Chicken Gallus gallus Q5ZMD1 245 27764 V46 E E R N L L S V A Y K N V V G
Frog Xenopus laevis Q5XHK2 244 27740 V46 E E R N L L S V A Y K N V V G
Zebra Danio Brachydanio rerio Q7T356 242 27374 S45 N E E R N L L S V A Y K N V V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29310 248 28209 V49 E E R N L L S V A Y K N V V G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q20655 248 28049 V48 E E R N L L S V A Y K N V V G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q01525 259 29143 Y52 R N L L S V A Y K N V I G A R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 44.7 99.5 97.9 N.A. 96.3 69.7 N.A. 90.7 68.5 66.5 68.9 N.A. 64.9 N.A. 64.5 N.A.
Protein Similarity: 100 54.4 100 98.7 N.A. 97.9 83 N.A. 93.9 84.6 81.4 82.6 N.A. 79.8 N.A. 79.8 N.A.
P-Site Identity: 100 0 100 100 N.A. 100 0 N.A. 100 0 0 0 N.A. 0 N.A. 0 N.A.
P-Site Similarity: 100 13.3 100 100 N.A. 100 13.3 N.A. 100 13.3 13.3 13.3 N.A. 13.3 N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 58.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 72.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 80 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 93.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 47 0 47 8 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 47 54 8 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 47 39 47 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 47 0 47 8 0 0 0 % K
% Leu: 0 0 47 47 47 54 8 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 47 0 47 8 0 0 0 0 47 0 47 8 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 39 % Q
% Arg: 47 0 47 8 0 0 0 0 0 0 0 0 0 0 8 % R
% Ser: 0 0 0 0 47 0 47 8 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 47 0 47 8 0 47 39 47 54 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 47 0 47 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _