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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
OTX2
All Species:
28.48
Human Site:
S246
Identified Species:
62.67
UniProt:
P32243
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P32243
NP_068374.1
289
31636
S246
S
T
Q
G
Y
G
A
S
S
L
G
F
N
S
T
Chimpanzee
Pan troglodytes
XP_001163000
296
32257
S253
S
T
Q
G
Y
G
A
S
S
L
G
F
N
S
T
Rhesus Macaque
Macaca mulatta
NP_001171116
297
32414
S254
S
T
Q
G
Y
G
A
S
S
L
G
F
N
S
T
Dog
Lupus familis
XP_547830
289
31604
S246
S
T
Q
G
Y
G
A
S
S
L
G
F
N
S
T
Cat
Felis silvestris
Mouse
Mus musculus
P80206
289
31604
S246
S
T
Q
G
Y
G
A
S
S
L
G
F
N
S
T
Rat
Rattus norvegicus
Q63410
355
37584
H292
P
L
S
Q
S
S
G
H
H
H
H
H
H
H
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6DKN2
289
31671
S246
S
S
Q
A
Y
G
A
S
S
L
G
F
N
S
T
Zebra Danio
Brachydanio rerio
Q91981
289
31576
S246
P
T
Q
G
Y
G
A
S
G
L
G
F
N
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22810
542
55168
N260
S
N
N
N
N
Q
G
N
S
T
P
N
S
S
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q93356
278
30883
S231
S
S
L
P
T
T
S
S
S
L
S
V
Y
N
Y
Sea Urchin
Strong. purpuratus
Q26417
371
41197
M327
H
Q
M
A
A
S
A
M
N
N
G
P
M
T
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.3
96.3
99.3
N.A.
99.6
55.2
N.A.
N.A.
N.A.
94.4
93.7
N.A.
26
N.A.
31.4
41.2
Protein Similarity:
100
97.3
96.3
99.6
N.A.
100
61.9
N.A.
N.A.
N.A.
96.8
96.5
N.A.
35.7
N.A.
46.7
51.2
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
N.A.
N.A.
86.6
86.6
N.A.
20
N.A.
26.6
20
P-Site Similarity:
100
100
100
100
N.A.
100
6.6
N.A.
N.A.
N.A.
93.3
86.6
N.A.
40
N.A.
46.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
19
10
0
73
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
64
0
0
0
% F
% Gly:
0
0
0
55
0
64
19
0
10
0
73
0
0
0
0
% G
% His:
10
0
0
0
0
0
0
10
10
10
10
10
10
10
10
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
10
0
0
0
0
0
0
73
0
0
0
0
0
% L
% Met:
0
0
10
0
0
0
0
10
0
0
0
0
10
0
0
% M
% Asn:
0
10
10
10
10
0
0
10
10
10
0
10
64
10
0
% N
% Pro:
19
0
0
10
0
0
0
0
0
0
10
10
0
0
0
% P
% Gln:
0
10
64
10
0
10
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
73
19
10
0
10
19
10
73
73
0
10
0
10
73
10
% S
% Thr:
0
55
0
0
10
10
0
0
0
10
0
0
0
10
73
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
64
0
0
0
0
0
0
0
10
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _