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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MC4R
All Species:
5.15
Human Site:
S25
Identified Species:
12.59
UniProt:
P32245
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P32245
NP_005903.2
332
36943
S25
R
S
S
Y
R
L
H
S
N
A
S
E
S
L
G
Chimpanzee
Pan troglodytes
Q9TT23
325
36628
N25
E
G
N
L
S
G
P
N
V
K
N
K
S
S
P
Rhesus Macaque
Macaca mulatta
Q864J4
317
34745
G25
P
T
A
T
P
H
L
G
L
A
A
N
Q
T
G
Dog
Lupus familis
XP_541099
632
70219
T324
L
D
L
N
S
N
A
T
E
G
N
F
S
G
P
Cat
Felis silvestris
Mouse
Mus musculus
P56450
332
36970
S25
R
S
S
Y
G
L
H
S
N
A
S
E
S
L
G
Rat
Rattus norvegicus
P70596
332
36868
G25
R
S
S
H
G
L
H
G
N
A
S
E
S
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505445
334
36107
A26
S
Q
G
L
A
G
T
A
P
E
A
P
G
Q
G
Chicken
Gallus gallus
NP_001026685
331
36978
G25
Q
S
N
G
L
H
R
G
A
S
E
P
S
A
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_775385
326
36403
K25
Q
G
A
L
P
V
G
K
P
S
H
G
D
R
G
Tiger Blowfish
Takifugu rubipres
NP_001027732
322
35956
P25
Q
T
P
E
T
D
F
P
N
E
E
K
E
S
S
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
61.7
47.8
35.9
N.A.
93.6
93.3
N.A.
82.3
87
N.A.
69.8
66.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
75.3
64.4
44.1
N.A.
97.2
96.9
N.A.
87.7
91.5
N.A.
81.3
79.2
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
13.3
6.6
N.A.
93.3
80
N.A.
6.6
13.3
N.A.
6.6
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
33.3
33.3
20
N.A.
93.3
86.6
N.A.
20
33.3
N.A.
33.3
26.6
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
20
0
10
0
10
10
10
40
20
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
10
0
0
0
0
0
0
10
0
0
% D
% Glu:
10
0
0
10
0
0
0
0
10
20
20
30
10
0
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
10
0
0
0
% F
% Gly:
0
20
10
10
20
20
10
30
0
10
0
10
10
10
60
% G
% His:
0
0
0
10
0
20
30
0
0
0
10
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
10
0
10
0
20
0
0
10
% K
% Leu:
10
0
10
30
10
30
10
0
10
0
0
0
0
30
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
20
10
0
10
0
10
40
0
20
10
0
0
0
% N
% Pro:
10
0
10
0
20
0
10
10
20
0
0
20
0
0
20
% P
% Gln:
30
10
0
0
0
0
0
0
0
0
0
0
10
10
0
% Q
% Arg:
30
0
0
0
10
0
10
0
0
0
0
0
0
10
0
% R
% Ser:
10
40
30
0
20
0
0
20
0
20
30
0
60
20
10
% S
% Thr:
0
20
0
10
10
0
10
10
0
0
0
0
0
10
0
% T
% Val:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _